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Title: Anti-inflammatory, Antioxidant Activities and Safety of Coffea arabica Leaf Extract for Alternative Cosmetic Ingredient
Authors: Kanokwan Kiattisin
Nichcha Nitthikan
Worrapan Poomanee
Pimporn Leelapornpisid
Helmut Viernstein 
Monika Mueller
Keywords: Coffea arabica
leaf extract
anti-inflammatory activity
irritation test
Issue Date: 2019
Publisher: Science Faculty of Chiang Mai University
Citation: Chiang Mai Journal of Science 46, 2 (Mar 2019), 284 - 294
Abstract: Coffee (Coffea arabica) or Arabica is grown as an economic cash crop in the northern highlands of Thailand. Utilization of coffee leaves has historically been overshadowed by coffee bean products. Phytochemical constituents, antioxidant and anti-inflammatory activities as well as irritation of Thai arabica coffee leaf extract were evaluated. The leaf extract demonstrated potential antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging, and lipid peroxidation inhibition assays, with high phenolic content and flavonoid content. Anti-inflammatory potential was observed in dose-dependent manner by reducing interleukin-6 (IL-6) secretion from LPS-stimulated macrophages. Irritation on the chorioallantoic membrane of hen’s eggs were not observed. Therefore, coffee leaf extract has potential as the new alternative ingredient for cosmetics or cosmeceutical products. Moreover, this research has benefit for adding the value to the coffee leaves in off-season for coffee beans.
ISSN: 0125-2526
Appears in Collections:CMUL: Journal Articles

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