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dc.contributor.authorKanokwan Kiattisinen_US
dc.contributor.authorNichcha Nitthikanen_US
dc.contributor.authorWorrapan Poomaneeen_US
dc.contributor.authorPimporn Leelapornpisiden_US
dc.contributor.authorHelmut Viernstein en_US
dc.contributor.authorMonika Muelleren_US
dc.identifier.citationChiang Mai Journal of Science 46, 2 (Mar 2019), 284 - 294en_US
dc.description.abstractCoffee (Coffea arabica) or Arabica is grown as an economic cash crop in the northern highlands of Thailand. Utilization of coffee leaves has historically been overshadowed by coffee bean products. Phytochemical constituents, antioxidant and anti-inflammatory activities as well as irritation of Thai arabica coffee leaf extract were evaluated. The leaf extract demonstrated potential antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging, and lipid peroxidation inhibition assays, with high phenolic content and flavonoid content. Anti-inflammatory potential was observed in dose-dependent manner by reducing interleukin-6 (IL-6) secretion from LPS-stimulated macrophages. Irritation on the chorioallantoic membrane of hen’s eggs were not observed. Therefore, coffee leaf extract has potential as the new alternative ingredient for cosmetics or cosmeceutical products. Moreover, this research has benefit for adding the value to the coffee leaves in off-season for coffee beans.en_US
dc.publisherScience Faculty of Chiang Mai Universityen_US
dc.subjectCoffea arabicaen_US
dc.subjectleaf extracten_US
dc.subjectanti-inflammatory activityen_US
dc.subjectirritation testen_US
dc.titleAnti-inflammatory, Antioxidant Activities and Safety of Coffea arabica Leaf Extract for Alternative Cosmetic Ingredienten_US
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