Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/77315
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dc.contributor.authorSiriporn Okonogien_US
dc.contributor.authorAdchareeya Kaewpintaen_US
dc.contributor.authorPisaisit Chaijareenonten_US
dc.date.accessioned2022-10-16T07:27:21Z-
dc.date.available2022-10-16T07:27:21Z-
dc.date.issued2021-04-01en_US
dc.identifier.issn19994923en_US
dc.identifier.other2-s2.0-85103894118en_US
dc.identifier.other10.3390/pharmaceutics13040449en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85103894118&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/77315-
dc.description.abstractCarbamide peroxide (CP), a tooth whitening agent, is chemically unstable. The present study explores stability enhancement of CP by loading in a nanofibrous film (CP-F) composed of polyvinyl alcohol/polyvinylpyrrolidone/silica mixture, using an electrospinning technique. Kept at a temperature range of 60–80◦C for 6 h, CP in CP-F showed significantly higher stability than that in a polymer solution and in water, respectively. Degradation of CP in CP-F could be described by the first order kinetics with the predicted half-life by the Arrhenius equation of approximately 6.52 years. Physicochemical properties of CP-F after long-term storage for 12 months at different temperatures and relative humidity (RH) were investigated using scanning electron microscopy, X-ray diffractometry, differential scanning calorimetry, and Fourier transform infrared spectroscopy. It was found that high temperature and high humidity (45◦C/75% RH) could enhance water absorption and destruction of the nanofibrous structure of CP-F. Interestingly, kept at 25◦C/30% RH, the nanofibrous structure of CP-F was not damaged, and exhibited no water absorption. Moreover, the remaining CP, the mechanical properties, and the adhesive properties of CP-F were not significantly changed in this storage condition. It is concluded that the developed CP-F and a suitable storage condition can significantly improve CP stability.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleStability and influence of storage conditions on nanofibrous film containing tooth whitening agenten_US
dc.typeJournalen_US
article.title.sourcetitlePharmaceuticsen_US
article.volume13en_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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