Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/77303
Full metadata record
DC FieldValueLanguage
dc.contributor.authorNapapan Kangwanen_US
dc.contributor.authorKomsak Pinthaen_US
dc.contributor.authorChakkrit Khanareeen_US
dc.contributor.authorSarawut Kongkarnkaen_US
dc.contributor.authorTeera Chewonarinen_US
dc.contributor.authorMaitree Suttajiten_US
dc.date.accessioned2022-10-16T07:26:47Z-
dc.date.available2022-10-16T07:26:47Z-
dc.date.issued2021-10-01en_US
dc.identifier.issn17359414en_US
dc.identifier.issn17355362en_US
dc.identifier.other2-s2.0-85113762026en_US
dc.identifier.other10.4103/1735-5362.323913en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85113762026&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/77303-
dc.description.abstractBackground and purpose: Ulcerative colitis is a chronic inflammatory bowel disease that involves diffused inflammation of the large intestine. Omega-3 fatty acid (FA) has been known to regulate the inflammatory response associated with ulcerative colitis pathogenesis. Perilla frutescens is a valuable source of omega-3 FA and α-linolenic acid (ALA) contained in its seed oil. Therefore, the aim of this study was to evaluate the anti-inflammatory effect of Perilla seed oil (PSO) on colitis induced by dextran sulfate sodium (DSS) in a mouse model. Experimental approach: PSO was extracted using a cold-pressed extractor and FA composition of PSO was analyzed by GC-MS. Acute colitis in mice was induced with 3% DSS in drinking water for 7 days. Some mice were treated with PSO (20, 100, 200 mg/kg BW) for 3 weeks before the DSS administration. Sulfasalazine was used as a positive control. The clinical features, histopathologic, serum, and gene expression of proinflammatory cytokines in the colon were assessed. Finding/Results: PSO contained the highest proportion of ALA (61.51%). Furthermore, PSO pretreatment evidently reduced body weight loss, diminished diarrhea, gross bleeding, and DSS-induced colon shortening. PSO pretreatment attenuated histopathological changes in response to DSS-induced colitis. PSO pretreatment also markedly decreased inflammatory response in serum and the colon tissue of DSS-induced mice. Conclusion and implication: ALA in PSO is suggested to be mainly responsible for the reduction of DSS-induced colitis through suppressing inflammatory markers. PSO could be further developed as a functional health supplement, which would be beneficial for anti-inflammation in the colonic mucosa.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleAnti-inflammatory effect of Perilla frutescens seed oil rich in omega-3 fatty acid on dextran sodium sulfate-induced colitis in miceen_US
dc.typeJournalen_US
article.title.sourcetitleResearch in Pharmaceutical Sciencesen_US
article.volume16en_US
article.stream.affiliationsChiang Rai Rajabhat Universityen_US
article.stream.affiliationsUniversity of Phayaoen_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.