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dc.contributor.authorBenjamin Ongnoken_US
dc.contributor.authorThawatchai Khuanjingen_US
dc.contributor.authorTitikorn Chunchaien_US
dc.contributor.authorPatcharapong Pantiyaen_US
dc.contributor.authorSasiwan Kerdphooen_US
dc.contributor.authorBusarin Arunsaken_US
dc.contributor.authorWichwara Nawaraen_US
dc.contributor.authorThidarat Jaiwongkamen_US
dc.contributor.authorNattayaporn Apaijaien_US
dc.contributor.authorNipon Chattipakornen_US
dc.contributor.authorSiriporn C. Chattipakornen_US
dc.description.abstractAlthough doxorubicin (Dox) is an effective chemotherapy medication used extensively in the treatment of breast cancer, it frequently causes debilitating neurological deficits known as chemobrain. Donepezil (DPZ), an acetylcholinesterase inhibitor, provides therapeutic benefits in various neuropathological conditions. However, comprehensive mechanistic insights regarding the neuroprotection of DPZ on cognition and brain pathologies in a Dox-induced chemobrain model remain obscure. Here, we demonstrated that Dox-treated rats manifested conspicuous cognitive deficits and developed chemobrain pathologies as indicated by brain inflammatory and oxidative insults, glial activation, defective mitochondrial homeostasis, increased potential lesions associated with Alzheimer’s disease, disrupted neurogenesis, loss of dendritic spines, and ultimately neuronal death through both apoptosis and necroptosis. Intervention with DPZ co-treatment completely restored cognitive function by attenuating these pathological conditions induced by DOX. We also confirmed that DPZ treatment does not affect the anti-cancer efficacy of Dox in breast cancer cells. Together, our findings suggest that DPZ treatment confers potential neuroprotection against Dox-induced chemobrain.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleDonepezil Protects Against Doxorubicin-Induced Chemobrain in Rats via Attenuation of Inflammation and Oxidative Stress Without Interfering With Doxorubicin Efficacyen_US
article.volume18en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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