Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/77031
Title: Nationwide surveillance and molecular characterization of critically drug-resistant gram-negative bacteria: Results of the research university network Thailand study
Authors: Thitiya Yungyuen
Tanittha Chatsuwan
Rongpong Plongla
Sakawrat Kanthawong
Umaporn Yordpratum
Supayang P. Voravuthikunchai
Sarunyou Chusri
Dennapa Saeloh
Worada Samosornsuk
Nuntra Suwantarat
Romanee Chaiwarith
Surat Wannalerdsakun
Porpon Rotjanapan
Prawat Chantharit
Orawan Tulyaprawat
Iyarit Thaipisuttikul
Pattarachai Kiratisin
Pakpiengpen Sornwiboonsak
Nanthawadee Thongnark
Niporn Thepchai
Pattraporn Ponglorpisit
Pimpa Rungnobhakhun
Wijittraporn Onraj
Piyanat Pitakwong
Watchanarat Nitchot
Jareerat Saensud
Jintana Phimsen
Theerasak Jaifoo
Nuttiya Srisurat
Krittika Kamlangharn
Napawan Punakabutra
Sirirat Lukin
Nalinwan Wongsawat
Supat Nantasan
Kanokwan Saengsawang
Thitirat Tangkosakul
Parichat Boonrod
Nattagarn Chuenchom
Thanee Wongchai
Phadungkiat Khamnoi
Khanuengnit Nuket
Wilawan Thipmontri
Athita Riwlord
Surachai Jirapornchai
Patcharee Runapong
Sutas Boonyong
Pongpol Rerknawarat
Uraiwan Surin
Poramed Winichakoon
Pisitphon Chaimongkhol
Sarunya Srijuntongsiri
Tanatporn Chuenkeson
Patsanporn Nontaratron
Palakorn Srinitiwat
Khoriah Chedee
Vichaya Yavichai
Nutchada Tanburawong
Jirayu Visuthranukul
Umnat Klamem
Nithiarphar Bamrungsri
Pathanith Aranya
Malee Techapornrung
Sasitorn Thaicharoen
Teerarat Shanthachol
Suwimol Chooprayoon
Sarobon Chaudakshetrin
Somjit Chinapak
Narisorn Lorchirachoonkul
Puncharat Wongut-Sa
Tidarat Suttiraksa
Pachara Kasemsiri
Waranya Srichunta
Sitthipong Dumrongpiwat
Chonteera Charoenchai
Wittaya Wangsomboonsiri
Kwanjai Ketwong
Sujinda Ruangchan
Benjamat Jareeyaphadub
Sarawut Promsen
Jiraporn Nilsakul
Sunee Chayangsu
Saowarat Deekae
Huttaya Thuncharoon
Patcharee Choochur
Narissara Mungkornkaew
Chitprasong Malaisri
Yaowares Panjakun
Adisak Sangchankoom
Sarochin Pangnakorn
Tananun Tanpaibule
Daranee Nutalai
Pannawadee Uppathamnarakorn
Warattaya Ueaphathanaphanich
Nutwariya Homsukon
Narumol Boonchaiyang
Authors: Thitiya Yungyuen
Tanittha Chatsuwan
Rongpong Plongla
Sakawrat Kanthawong
Umaporn Yordpratum
Supayang P. Voravuthikunchai
Sarunyou Chusri
Dennapa Saeloh
Worada Samosornsuk
Nuntra Suwantarat
Romanee Chaiwarith
Surat Wannalerdsakun
Porpon Rotjanapan
Prawat Chantharit
Orawan Tulyaprawat
Iyarit Thaipisuttikul
Pattarachai Kiratisin
Pakpiengpen Sornwiboonsak
Nanthawadee Thongnark
Niporn Thepchai
Pattraporn Ponglorpisit
Pimpa Rungnobhakhun
Wijittraporn Onraj
Piyanat Pitakwong
Watchanarat Nitchot
Jareerat Saensud
Jintana Phimsen
Theerasak Jaifoo
Nuttiya Srisurat
Krittika Kamlangharn
Napawan Punakabutra
Sirirat Lukin
Nalinwan Wongsawat
Supat Nantasan
Kanokwan Saengsawang
Thitirat Tangkosakul
Parichat Boonrod
Nattagarn Chuenchom
Thanee Wongchai
Phadungkiat Khamnoi
Khanuengnit Nuket
Wilawan Thipmontri
Athita Riwlord
Surachai Jirapornchai
Patcharee Runapong
Sutas Boonyong
Pongpol Rerknawarat
Uraiwan Surin
Poramed Winichakoon
Pisitphon Chaimongkhol
Sarunya Srijuntongsiri
Tanatporn Chuenkeson
Patsanporn Nontaratron
Palakorn Srinitiwat
Khoriah Chedee
Vichaya Yavichai
Nutchada Tanburawong
Jirayu Visuthranukul
Umnat Klamem
Nithiarphar Bamrungsri
Pathanith Aranya
Malee Techapornrung
Sasitorn Thaicharoen
Teerarat Shanthachol
Suwimol Chooprayoon
Sarobon Chaudakshetrin
Somjit Chinapak
Narisorn Lorchirachoonkul
Puncharat Wongut-Sa
Tidarat Suttiraksa
Pachara Kasemsiri
Waranya Srichunta
Sitthipong Dumrongpiwat
Chonteera Charoenchai
Wittaya Wangsomboonsiri
Kwanjai Ketwong
Sujinda Ruangchan
Benjamat Jareeyaphadub
Sarawut Promsen
Jiraporn Nilsakul
Sunee Chayangsu
Saowarat Deekae
Huttaya Thuncharoon
Patcharee Choochur
Narissara Mungkornkaew
Chitprasong Malaisri
Yaowares Panjakun
Adisak Sangchankoom
Sarochin Pangnakorn
Tananun Tanpaibule
Daranee Nutalai
Pannawadee Uppathamnarakorn
Warattaya Ueaphathanaphanich
Nutwariya Homsukon
Narumol Boonchaiyang
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Sep-2021
Abstract: A large-scale surveillance is an important measure to monitor the regional spread of antimicrobial resistance. We prospectively studied the prevalence and molecular characteristics of clinically important Gram-negative bacilli, including Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii complex (ABC), and Pseudomonas aeruginosa, from blood, respiratory tract, urine, and sterile sites at 47 hospitals across Thailand. Among 187, 619 isolates, 93, 810 isolates (50.0%) were critically drug resistant, of which 12, 915 isolates (13.8%) were randomly selected for molecular characterization. E. coli was most commonly isolated from all specimens, except the respiratory tract, in which ABC was predominant. Prevalence of extendedspectrum cephalosporin resistance (ESCR) was higher in E. coli (42.5%) than K. pneumoniae (32.0%), but carbapenem-resistant (CR)-K. pneumoniae (17.2%) was 4.5-fold higher than CR-E. coli (3.8%). The majority of ESCR/CR-E. coli and K. pneumoniae isolates carried blaCTX-M (64.6% to 82.1%). BlaNDM and blaOXA-48-like were the most prevalent carbapenemase genes in CR-E. coli/CR-K. pneumoniae (74.9%/52.9% and 22.4%/ 54.1%, respectively). In addition, 12.9%/23.0% of CR-E. coli/CR-K. pneumoniae cocarried blaNDM and blaOXA-48-like. Among ABC isolates, 41.9% were extensively drug resistant (XDR) and 35.7% were multidrug resistant (MDR), while P. aeruginosa showed XDR/MDR at 6.3%/16.5%. A. baumannii was the most common species among ABC isolates. The major carbapenemase gene in MDR-A. baumannii/XDR-A. baumannii was blaOXA-23-like (85.8%/93.0%), which had much higher rates than other ABC species. BlaIMP, blaVIM, blaOXA-40-like, and blaOXA-58-like were also detected in ABC at lower rates. The most common carbapenemase gene in MDR/XDR-P. aeruginosa was blaIMP (29.0%/30.6%), followed by blaVIM (9.5%/25.3%). The findings reiterate an alarming situation of drug resistance that requires serious control measures.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85112850482&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/77031
ISSN: 10986596
00664804
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.