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dc.contributor.authorSirinart Sirilerten_US
dc.contributor.authorTheera Tongsongen_US
dc.contributor.authorSirinart Kumfuen_US
dc.contributor.authorSiriporn C. Chattipakornen_US
dc.contributor.authorNipon Chattipakornen_US
dc.description.abstractFoetal response to hepatitis B viral infection is still unknown. The mechanisms of persistent infection that occurs more often in mother-to-child transmission than adult transmission are also unclear. Various aspects of the environmental factors that accelerate or inhibit infection and the cytokine responses are associated with the persistence of infection. Several studies showed that the cytokine poor immune response in immaturity causes the persistence of the infection. However, some reports suggested that a mature immune response was the cause of this persistent infection. This review comprehensively summarized the reports from in vitro, in vivo as well as clinical reports regarding the responses of the foetuses of hepatitis B infected mothers to the micro-organism. The mechanism of more opportunities to be persistently infected via the mother-to-child transmission route is also summarized and discussed. Since there are limited clinical reports at this time, this review will provide evidence for future studies regarding the intrauterine infection mechanism and foetal response to hepatitis B virus to elucidate the mechanisms responsible for mother-to-child transmission. This understanding may lead to effective interventions to control mother-to-child hepatitis B infection in the future.en_US
dc.subjectImmunology and Microbiologyen_US
dc.titleEffects of intrauterine exposure to hepatitis B virus in foetusesen_US
article.title.sourcetitleJournal of Medical Microbiologyen_US
article.volume70en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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