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dc.contributor.authorMani Iyer Prasanthen_US
dc.contributor.authorDicson Sheeja Malaren_US
dc.contributor.authorPeriyanaina Kesikaen_US
dc.contributor.authorTewin Tencomnaoen_US
dc.contributor.authorBhagavathi Sundaram Sivamaruthien_US
dc.date.accessioned2022-10-16T07:15:18Z-
dc.date.available2022-10-16T07:15:18Z-
dc.date.issued2021-01-01en_US
dc.identifier.other2-s2.0-85129794271en_US
dc.identifier.other10.1016/B978-0-323-85170-1.00015-4en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85129794271&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/76683-
dc.description.abstractObesity is an outcome of irregular energy intake and balance, changes in gut microbiota, and improper diet, which is further influenced by the host’s genetic makeup and environmental factors. Several studies in vitro, in vivo, and human clinical trials have highlighted the influence of fermented food and microbes on obesity-associated consequences. They include probiotics, prebiotics, and synbiotics. Probiotics are defined as viable microorganisms that reach the intestine in an active state sufficient to exert positive health benefits. A prebiotic is “a selectively fermented ingredient that allows specific changes, both in the composition and/or activity in the gastrointestinal microbiota that confers benefits upon host well-being and health.” A synbiotic is a synergistic combination of both pre and probiotics. Here we try to explain the factors influencing obesity, the role of microbiome, and probiotic intervention in obesity. These effects could be attributed to their ability to alter the intestinal microbiota, remodeling the energy metabolism, alter the expression of genes related to thermogenesis, glucose metabolism, and lipid metabolism, and change the parasympathetic nerve activity. Further in-depth studies are necessary to identify the best probiotic or synbiotic mixture, optimum dosage, duration of the intervention, and mode of action to reduce obesity.en_US
dc.subjectHealth Professionsen_US
dc.subjectMedicineen_US
dc.titleImpact of probiotic supplementation and the role of gut microbiome in obesityen_US
dc.typeBooken_US
article.title.sourcetitleProbiotics: Advanced Food and Health Applicationsen_US
article.stream.affiliationsChulalongkorn Universityen_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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