Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/76227
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dc.contributor.authorThura Tun Ooen_US
dc.contributor.authorWasana Pratchayasakulen_US
dc.contributor.authorNipon Chattipakornen_US
dc.contributor.authorSiriporn C. Chattipakornen_US
dc.date.accessioned2022-10-16T07:07:11Z-
dc.date.available2022-10-16T07:07:11Z-
dc.date.issued2022-12-01en_US
dc.identifier.issn18729711en_US
dc.identifier.issn0161813Xen_US
dc.identifier.other2-s2.0-85138641365en_US
dc.identifier.other10.1016/j.neuro.2022.09.006en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85138641365&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/76227-
dc.description.abstractChemotherapy-induced neurotoxicity is one of the most prevalent side effects in cancer patients and survivors. Cognitive decline and peripheral neuropathy are the most common chemotherapy-induced neurotoxic symptoms. These symptoms lead not only to the limiting of the dose of chemotherapy given to cancer patients, but also have an impact on the quality of life of cancer survivors. Although the exact mechanisms involved in chemotherapy-induced neurotoxicity are still unclear, neuroinflammation is widely regarded as being one of the major causes involved in chemotherapy-induced neurotoxicity. It is known that Toll-like receptor 4 (TLR4) plays a critical role in the inflammatory process, and it has been recently reported that it is associated with chemotherapy-induced neurotoxicity. In this review, we summarize and discuss all available evidence regarding the activation of the TLR4 signaling pathway in various models of chemotherapy-induced neurotoxicity. This review also emphasizes the evidence pertinent to TLR4 inhibition on chemotherapy-induced neurotoxicity in rodent studies. Understanding the role of the TLR4 signaling pathway behind chemotherapy-induced neurotoxicity is crucial for improving treatments and ensuring the long-term survival of cancer patients.en_US
dc.subjectNeuroscienceen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleEmerging roles of toll-like receptor 4 in chemotherapy-induced neurotoxicityen_US
dc.typeJournalen_US
article.title.sourcetitleNeuroToxicologyen_US
article.volume93en_US
article.stream.affiliationsFaculty of Medicine, Chiang Mai Universityen_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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