Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/76160
Title: BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia-Pacific region
Authors: Dyna Khuon
Dhanushi Rupasinghe
Vonthanak Saphonn
Tsz Shan Kwong
Alvina Widhani
Romanee Chaiwarith
Penh Sun Ly
Cuong Duy Do
Anchalee Avihingsanon
Suwimon Khusuwan
Tuti Parwati Merati
Kinh Van Nguyen
Nagalingeswaran Kumarasamy
Yu Jiun Chan
Iskandar Azwa
Oon Tek Ng
Sasisopin Kiertiburanakul
Junko Tanuma
Sanjay Pujari
Rossana Ditangco
Fujie Zhang
Jun Yong Choi
Yasmin Gani
Shashikala Sangle
Jeremy Ross
Pamina M. Gorbach
Awachana Jiamsakul
Authors: Dyna Khuon
Dhanushi Rupasinghe
Vonthanak Saphonn
Tsz Shan Kwong
Alvina Widhani
Romanee Chaiwarith
Penh Sun Ly
Cuong Duy Do
Anchalee Avihingsanon
Suwimon Khusuwan
Tuti Parwati Merati
Kinh Van Nguyen
Nagalingeswaran Kumarasamy
Yu Jiun Chan
Iskandar Azwa
Oon Tek Ng
Sasisopin Kiertiburanakul
Junko Tanuma
Sanjay Pujari
Rossana Ditangco
Fujie Zhang
Jun Yong Choi
Yasmin Gani
Shashikala Sangle
Jeremy Ross
Pamina M. Gorbach
Awachana Jiamsakul
Keywords: Medicine
Issue Date: 1-Jan-2022
Abstract: Background: Non-Asian body mass index (BMI) classifications are commonly used as a risk factor for high fasting blood glucose (FBG). We investigated the incidence and factors associated with high FBG among people living with HIV in the Asia-Pacific region, using a World Health Organization BMI classification specific to Asian populations. Methods: This study included people living with HIV enrolled in a longitudinal cohort study from 2003 to 2019, receiving antiretroviral therapy (ART), and without prior tuberculosis. BMI at ART initiation was categorized using Asian BMI classifications: underweight (<18.5 kg/m2), normal (18.5–22.9 kg/m2), overweight (23–24.9 kg/m2), and obese (≥25 kg/m2). High FBG was defined as a single post-ART FBG measurement ≥126 mg/dL. Factors associated with high FBG were analyzed using Cox regression models stratified by site. Results: A total of 3939 people living with HIV (63% male) were included. In total, 50% had a BMI in the normal weight range, 23% were underweight, 13% were overweight, and 14% were obese. Median age at ART initiation was 34 years (interquartile range 29–41). Overall, 8% had a high FBG, with an incidence rate of 1.14 per 100 person-years. Factors associated with an increased hazard of high FBG included being obese (≥25 kg/m2) compared with normal weight (hazard ratio [HR] = 1.79; 95% confidence interval [CI] 1.31–2.44; p < 0.001) and older age compared with those aged ≤30 years (31–40 years: HR = 1.47; 95% CI 1.08–2.01; 41–50 years: HR = 2.03; 95% CI 1.42–2.90; ≥51 years: HR = 3.19; 95% CI 2.17–4.69; p < 0.001). Conclusion: People living with HIV with BMI >25 kg/m2 were at increased risk of high FBG. This indicates that regular assessments should be performed in those with high BMI, irrespective of the classification used.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85133752819&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/76160
ISSN: 14681293
14642662
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.