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dc.contributor.authorChuda Chittasuphoen_US
dc.contributor.authorJakrapong Angklomklewen_US
dc.contributor.authorThanu Thongnopkoonen_US
dc.contributor.authorWongwit Senavongseen_US
dc.contributor.authorPensak Jantrawuten_US
dc.contributor.authorWarintorn Ruksiriwanichen_US
dc.description.abstractA hydrogel scaffold is a localized drug delivery system that can maintain the therapeutic level of drug concentration at the tumor site. In this study, the biopolymer hydrogel scaffold encapsulating doxorubicin was fabricated from gelatin, sodium carboxymethyl cellulose, and gelatin/sodium carboxymethyl cellulose mixture using a lyophilization technique. The effects of a crosslinker on scaffold morphology and pore size were determined using scanning electron microscopy. The encapsulation efficiency and the release profile of doxorubicin from the hydrogel scaffolds were determined using UV-Vis spectrophotometry. The anti-proliferative effect of the scaffolds against the lung cancer cell line was investigated using an MTT assay. The results showed that scaffolds made from different types of natural polymer had different pore configurations and pore sizes. All scaffolds had high encapsulation efficiency and drug-controlled release profiles. The viability and proliferation of A549 cells, treated with gelatin, gelatin/SCMC, and SCMC scaffolds containing doxorubicin significantly decreased compared with control. These hydrogel scaffolds might provide a promising approach for developing a superior localized drug delivery system to kill lung cancer cells.en_US
dc.subjectMaterials Scienceen_US
dc.titleBiopolymer hydrogel scaffolds containing doxorubicin as a localized drug delivery system for inhibiting lung cancer cell proliferationen_US
article.volume13en_US Mai Universityen_US Universityen_US
Appears in Collections:CMUL: Journal Articles

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