Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/75726
Title: Structural determination, biological function, and molecular modelling studies of sulfoaildenafil adulterated in herbal dietary supplement
Authors: Kanchanok Kodchakorn
Nawarat Viriyakhasem
Tunchanok Wongwichai
Prachya Kongtawelert
Authors: Kanchanok Kodchakorn
Nawarat Viriyakhasem
Tunchanok Wongwichai
Prachya Kongtawelert
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 2-Feb-2021
Abstract: Unapproved ingredients included in herbal medicines and dietary supplements have been detected as adulterated synthetic drugs used for erectile dysfunction. Extraction from a dietary supplement was performed to isolate the compounds by HPLC analysis. The structural characterization was confirmed using mass spectrometry (ESI-TOF/MS and LC-MS/MS),1H NMR, and13C NMR spectroscopy techniques. Results identified the thus-obtained compound to be sulfoaildenafil, a thioketone analogue of sildenafil. The biological activities of this active compound have been focused for the first time by the experimental point of view performance in vitro. The results revealed that sulfoaildenafil can affect the therapeutic level of nitric oxide through the upregulation of nitric oxide synthase and phosphodiesterase type 5 (PDE5) gene expressions. This bulk material, which displays structural similarity to sildenafil, was analyzed for the presence of a PDE5 inhibitor using a theoretical calculation. These unique features of the potential activity of PDE5 protein and its inhibitors, sildenafil and sulfoaildenafil, may play a key consideration for understanding the mode of actions and predicting the biological activities of PDE5 inhibitors.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85102685361&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/75726
ISSN: 14203049
Appears in Collections:CMUL: Journal Articles

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