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dc.contributor.authorPhasit Charoenkwanen_US
dc.contributor.authorWatshara Shoombuatongen_US
dc.contributor.authorChalaithorn Nantasuphaen_US
dc.contributor.authorTanarat Muangmoolen_US
dc.contributor.authorPrapaporn Supraserten_US
dc.contributor.authorKittipat Charoenkwanen_US
dc.description.abstractRadical hysterectomy is a recommended treatment for early-stage cervical cancer. How-ever, the procedure is associated with significant morbidities resulting from the removal of the parametrium. Parametrial cancer invasion (PMI) is found in a minority of patients but the efficient system used to predict it is lacking. In this study, we develop a novel machine learning (ML)-based predictive model based on a random forest model (called iPMI) for the practical identification of PMI in women. Data of 1112 stage IA-IIA cervical cancer patients who underwent primary surgery were collected and considered as the training dataset, while data from an independent cohort of 116 consec-utive patients were used as the independent test dataset. Based on these datasets, iPMI-Econ was then developed by using basic clinicopathological data available prior to surgery, while iPMI-Power was also introduced by adding pelvic node metastasis and uterine corpus invasion to the iPMI-Econ. Both 10-fold cross-validations and independent test results showed that iPMI-Power outperformed other well-known ML classifiers (e.g., logistic regression, decision tree, k-nearest neighbor, multi-layer perceptron, naive Bayes, support vector machine, and extreme gradient boosting). Upon comparison, it was found that iPMI-Power was effective and had a superior performance to other well-known ML classifiers in predicting PMI. It is anticipated that the proposed iPMI may serve as a cost-effective and rapid approach to guide important clinical decision-making.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleArticle ipmi: Machine learning-aided identification of parametrial invasion in women with early-stage cervical canceren_US
article.volume11en_US Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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