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dc.contributor.authorJiraporn Kantapanen_US
dc.contributor.authorNathupakorn Dechsupaen_US
dc.contributor.authorDamrongsak Tippanyaen_US
dc.contributor.authorWannapha Nobnopen_US
dc.contributor.authorImjai Chitapanaruxen_US
dc.description.abstractCancer stem cells (CSCs) play a critical role in radiation resistance and recurrence. Thus, drugs targeting CSCs can be combined with radiotherapy to improve its antitumor efficacy. Here, we investigated whether a gallotannin extract from Bouea macrophylla seed (MPSE) and its main bioactive compound, pentagalloyl glucose (PGG), could suppress the stemness trait and further confer the radiosensitivity of head and neck squamous cell carcinoma (HNSCC) cell lines. In this study, we evaluate the effect of MPSE or PGG to suppress CSC‐like phenotypes and radiosensitiza-tion of HNSCC cell lines using a series of in vitro experiments, tumorsphere formation assay, colony formation assay, apoptosis assay, and Western blotting analysis. We demonstrate that MPSE or PGG is able to suppress tumorsphere formation and decrease protein expression of cancer stem cell markers. MPSE or PGG also enhanced the radiosensitivity in HNSCC cells. Pretreatment of cells with MPSE or PGG increased IR‐induced DNA damage (γ‐H2Ax) and enhanced radiation‐induced cell death. Notably, we observed that pretreatment with MPSE or PGG attenuated the IR‐induced stemness‐like properties characterized by tumorsphere formation and the CD44 CSC marker. Our findings describe a novel strategy for increasing therapeutic efficacy for head and neck cancer patients using the natural products MPSE and PGG.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemical Engineeringen_US
dc.subjectComputer Scienceen_US
dc.titleGallotannin from bouea macrophylla seed extract suppresses cancer stem‐like cells and radiosensitizes head and neck canceren_US
article.title.sourcetitleInternational Journal of Molecular Sciencesen_US
article.volume22en_US of Medicine, Chiang Mai Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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