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dc.contributor.authorKhajohnpat Boonpraserten_US
dc.contributor.authorYaoprapa Yunen_US
dc.contributor.authorWorapong Kosaruken_US
dc.contributor.authorPatcharapa Towiboonen_US
dc.contributor.authorPallop Tankaewen_US
dc.contributor.authorVeerasak Punyapornwithayaen_US
dc.contributor.authorThittaya Janyamathakulen_US
dc.contributor.authorPanida Muanghongen_US
dc.contributor.authorJanine L. Brownen_US
dc.contributor.authorChatchote Thitaramen_US
dc.contributor.authorChaleamchat Somgirden_US
dc.description.abstractElephant endotheliotropic herpesvirus hemorrhagic disease (EEHV-HD) is a virulent disease that causes severe hemorrhage and sudden death in Asian elephant calves. A change in hematology profiles is one indicator of infection before clinical signs appear; however, to be effective, individual baselines and age-matched reference values are needed. Stress has been speculated to be a factor in clinical EEHV cases, but relationships have not been demonstrated empirically. This study evaluated blood hematology and several stress response markers—salivary cortisol, fecal glucocorticoid metabolites (FGM), salivary Immunoglobulin A (SIgA), and fecal IgA (FIgA) in samples collected for 1 year from three healthy calves with no EEHV history (non-EEHV), and six that had previously been infected, developed clinical signs and survived (prior-EEHV). Hematology values between non-EEHV and prior-EEHV elephants were not different and within published reference ranges. Concentrations of salivary cortisol, FGM, SIgA, and FIgA also were variable and showed seasonal differences, but no relationships to prior EEHV status. One of the prior EEHV calves became re-infected, developed hemorrhagic disease (HD), and died during the study period. That calf exhibited lymphocytopenia, monocytopenia, and thrombocytopenia. Additionally, all stress biomarker concentrations were lower in the 12 days before viremia was observed. Thus, as in other studies, changes in hematology occur with EEHV infection, while preliminary data in one calf suggests that stress-response measures might also be informative and should be studied further.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.titleA longitudinal study of hematology and stress biomarker profiles in young asian elephants (Elephas maximus) in relation to elephant endotheliotropic herpesvirus (eehv) in Thailanden_US
article.volume11en_US and Research Center (National Zoo)en_US Mai Universityen_US Taeng Elephant Park and Clinicen_US Elephant Farmen_US
Appears in Collections:CMUL: Journal Articles

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