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dc.contributor.authorBaramee Chanabodeechalermrungen_US
dc.contributor.authorTanpong Chaiwariten_US
dc.contributor.authorSarana Rose Sommanoen_US
dc.contributor.authorPornchai Rachtanapunen_US
dc.contributor.authorNutthapong Kantrongen_US
dc.contributor.authorChuda Chittasuphoen_US
dc.contributor.authorPensak Jantrawuten_US
dc.date.accessioned2022-10-16T06:45:30Z-
dc.date.available2022-10-16T06:45:30Z-
dc.date.issued2022-09-01en_US
dc.identifier.issn20770375en_US
dc.identifier.other2-s2.0-85138675799en_US
dc.identifier.other10.3390/membranes12090825en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85138675799&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/74627-
dc.description.abstractComposite bacterial cellulose (BC) based hydrogel with alginate (A) or pectin (P) or alginate and pectin was fabricated via a physical crosslinking technique using calcium chloride (CaCl2) solution and incorporated with polyhexamethylene biguanide (PHMB) as an effective antimicrobial drug by immersion method. After that, the physicochemical properties of all hydrogel formulations were characterized. The result showed that the formulations with PHMB performed better physicochemical properties than the hydrogel without PHMB. Fourier transform infrared spectroscopy (FT-IR) showed the interaction between PHMB and the carboxylic group of alginate and pectin. BC/A-PHMB hydrogel performed suitable mechanical strength, fluid uptake ability, water retention property, drug content, high integrity value, and maximum swelling degree. Moreover, in vitro cell viability of BC/A-PHMB hydrogel revealed high biocompatibility with human keratinocyte cell line (HaCaT) and demonstrated prolong released of PHMB in Tris-HCl buffer pH 7.4, while rapid release in phosphate buffer saline pH 7.4. BC/A-PHMB hydrogel demonstrated good anti-bacterial activity against S. aureus and P. aeruginosa. In conclusion, BC/A-PHMB hydrogel could be a potential dual crosslinked ion-based hydrogel for wound dressing with anti-bacterial activity.en_US
dc.subjectChemical Engineeringen_US
dc.titleDual Crosslinked Ion-Based Bacterial Cellulose Composite Hydrogel Containing Polyhexamethylene Biguanideen_US
dc.typeJournalen_US
article.title.sourcetitleMembranesen_US
article.volume12en_US
article.stream.affiliationsKhon Kaen Universityen_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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