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dc.contributor.authorLingling Huangen_US
dc.contributor.authorPalin Sililasen_US
dc.contributor.authorChanisa Thonusinen_US
dc.contributor.authorTheera Tongsongen_US
dc.contributor.authorSuchaya Luewanen_US
dc.contributor.authorNipon Chattipakornen_US
dc.contributor.authorSiriporn C. Chattipakornen_US
dc.date.accessioned2022-10-16T06:44:44Z-
dc.date.available2022-10-16T06:44:44Z-
dc.date.issued2022-01-01en_US
dc.identifier.issn23523840en_US
dc.identifier.issn14992671en_US
dc.identifier.other2-s2.0-85134603174en_US
dc.identifier.other10.1016/j.jcjd.2022.05.009en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85134603174&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/74581-
dc.description.abstractObjectives: At the time of diagnosis, the blood glucose of women with gestational diabetes mellitus (GDM) who require subsequent insulin treatment does not differ from that of women with adequate diet control. Hence, in this study, we aimed to determine the role of maternal gut microbiota as a marker of insulin necessity in GDM and to identify the effect of insulin therapy on gut microbiota composition in GDM mothers and their newborns. Methods: Seventy-one pregnant women were enrolled onto the study, including 38 GDM and 33 non-GDM participants. During the follow-up period, 8 of the 38 GDM subjects required insulin therapy (GDM-I group), whereas 30 of the 38 GDM cases with sufficient glycemic control by diet alone (GDM-D group). Maternal blood and feces were obtained at the time of GDM diagnosis (pretreatment; 24 to 28 weeks of gestation) and before delivery (posttreatment; ≥37 weeks of gestation). Meconium and first feces of the newborns were also collected. Results: Pretreatment, the glycemic profile did not differ between the GDM-D and GDM-I groups. However, the proportions of Clostridiales, Lactobacillus and Bacteroidetes were higher in the GDM-I group than in the non-GDM and GDM-D groups. After treatment, gut microbiota composition showed no difference between non-GDM and GDM-I groups. Interestingly, a higher Firmicutes/Bacteroidetes (F/B) ratio was displayed in GDM-D mothers at posttreatment, and this was also observed in both meconium and first feces of GDM-D newborns. Conclusion: Insulin therapy changed maternal gut microbiota composition, which could be transferable to the mothers’ newborns.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMedicineen_US
dc.titleAssociation Between Gut Microbiota and Insulin Therapy in Women With Gestational Diabetes Mellitusen_US
dc.typeJournalen_US
article.title.sourcetitleCanadian Journal of Diabetesen_US
article.stream.affiliationsFaculty of Medicine, Chiang Mai Universityen_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsYoujiang Medical University for Nationalitiesen_US
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