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dc.contributor.authorHainan Yueen_US
dc.contributor.authorPu Songen_US
dc.contributor.authorNutda Sutthammikornen_US
dc.contributor.authorYoshie Umeharaen_US
dc.contributor.authorJuan Valentin Trujillo-Paezen_US
dc.contributor.authorHai Le Thanh Nguyenen_US
dc.contributor.authorMiho Takahashien_US
dc.contributor.authorGe Pengen_US
dc.contributor.authorRisa Ikutamaen_US
dc.contributor.authorKo Okumuraen_US
dc.contributor.authorHideoki Ogawaen_US
dc.contributor.authorShigaku Ikedaen_US
dc.contributor.authorFrançois Niyonsabaen_US
dc.description.abstractImpaired keratinocyte functions are major factors that are responsible for delayed diabetic wound healing. In addition to its antimicrobial activity, the antimicrobial peptide derived from insulin-like growth factor-binding protein 5 (AMP-IBP5) activates mast cells and promotes keratinocyte and fibroblast proliferation and migration. However, its effects on diabetic wound healing remain unclear. Human keratinocytes were cultured in normal or high glucose milieus. The production of angiogenic growth factor and cell proliferation and migration were evaluated. Wounds in normal and streptozotocin-induced diabetic mice were monitored and histologically examined. We found that AMP-IBP5 rescued the high glucose-induced attenuation of proliferation and migration as well as the production of angiogenin and vascular endothelial growth factors in keratinocytes. The AMP-IBP5-induced activity was mediated by the epidermal growth factor receptor, signal transducer and activator of transcription 1 and 3, and mitogen-activated protein kinase pathways, as indicated by the inhibitory effects of pathway-specific inhibitors. In vivo, AMP-IBP5 markedly accelerated wound healing, increased the expression of angiogenic factors and promoted vessel formation in both normal and diabetic mice. Overall, the finding that AMP-IBP5 accelerated diabetic wound healing by protecting against glucotoxicity and promoting angiogenesis suggests that AMP-IBP5 might be a potential therapeutic target for treating chronic diabetic wounds.en_US
dc.titleAntimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healingen_US
article.title.sourcetitleWound Repair and Regenerationen_US
article.volume30en_US University Graduate School of Medicineen_US Hospitalen_US Universityen_US Mai Universityen_US School of Medicineen_US
Appears in Collections:CMUL: Journal Articles

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