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dc.contributor.authorPatarapan Trakoolthongen_US
dc.contributor.authorNaphatsorn Ditthawuttikulen_US
dc.contributor.authorBhagavathi Sundaram Sivamaruthien_US
dc.contributor.authorSasithorn Sirilunen_US
dc.contributor.authorWandee Rungseevijitprapaen_US
dc.contributor.authorSartjin Peerajanen_US
dc.contributor.authorChaiyavat Chaiyasuten_US
dc.description.abstractMomordica charantia (M. charantia) is rich in flavonoids, which possess a strong antioxidant capacity and may help prevent hair loss. This study aims to develop the microemulsion of M. charantia with antioxidant activity and 5α-reductase (5aR) inhibitory activity. The total phenolic content (TPC), antioxidant activity, and 5aR inhibitory activity of ethanolic and aqueous extracts of the fruit were investigated. The preparation of M. charantia extract-loaded microemulsion (MELM) was optimized and characterized the MELM. The aqueous extract of M. charantia fruit flesh displayed a TPC of 780.75 ± 24.82 mg Gallic acid equivalence/g of extract. ABTS (2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid), DPPH (2,2-diphenyl-1-picrylhydrazyl), and nitric oxide (NO) radical scavenging activities were observed in all the extracts. About 0.461 ± 0.003 mg finasteride equivalence/g of extract of 5aR inhibitory activity was detected in the aqueous extract of the inner tissue of M. charantia fruit. Based on NO radical scavenging and 5aR inhibitory activity, an aqueous extract of the inner tissue (pericarp with seed) of M. charantia fruit was used to prepare the MELM. The MELM was prepared using a different ratio of tween 80 and ethanol as Smix. The results showed that the 1:1 ratio of tween 80: ethanol produced microemulsion of an optimum size, zeta potential, and polydispersity index. The MELM samples were stored at 5, 30, and 40◦ C for 12 weeks, and the stability was assessed. The results revealed that the size, zeta potential, and polydispersity index of the formulated MELM remained unchanged during the investigated time. This study primarily reports the 5aR inhibitory activity of M. charantia extract and the development of microemulsion. The prepared MELM could be further developed into cosmetic or pharmacological preparations to manage hair loss.en_US
dc.subjectChemical Engineeringen_US
dc.subjectComputer Scienceen_US
dc.subjectMaterials Scienceen_US
dc.subjectPhysics and Astronomyen_US
dc.titleAntioxidant and 5α-Reductase Inhibitory Activity of Momordica charantia Extract, and Development and Characterization of Microemulsionen_US
article.title.sourcetitleApplied Sciences (Switzerland)en_US
article.volume12en_US Ratchathani Universityen_US Fah Luang Universityen_US Mai Universityen_US Innovation Instituteen_US
Appears in Collections:CMUL: Journal Articles

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