Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/72563
Title: Phytochemical Analysis and Antioxidant, Antimicrobial, and Antiaging Activities of Ethanolic Seed Extracts of Four Mucuna Species
Authors: Tinnakorn Theansungnoen
Nichcha Nitthikan
Mayuramas Wilai
Phanuphong Chaiwut
Kanokwan Kiattisin
Aekkhaluck Intharuksa
Keywords: Biochemistry, Genetics and Molecular Biology
Chemical Engineering
Medicine
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Feb-2022
Abstract: The investigation into promising botanical materials for natural cosmetics is expanding due to environmental and health awareness. Here, we aimed to evaluate the phytochemical substances and the potential skin-related pharmacological activities of four Mucuna seeds, namely M. gigantea (Willd.) DC. (MGG), M. interrupta Gagnep. (MIT), M. monosperma Wight (MMM), and M. pruriens (L.) DC. (MPR), belonging to the Fabaceae family. In methodology, the Mucuna seeds were authenticated using morphological and molecular approaches. L-DOPA, phenolics, and flavonoid content, incorporated with HPLC and GC–MS fingerprinting analyses, were determined. Then, skin-related antimicrobial, antioxidant, and antiaging activities were determined. The results revealed that MPR showed the highest L-DOPA content (75.94 mg/100 mg extract), whereas MGG exhibited the highest phenolic and flavonoid content (56.73 ± 0.62 mg gallic/g extract and 1030.11 ± 3.97 mg quercetin/g extract, respectively). Only MMM and MPR could inhibit all of S. aureus, S. epidermidis, and C. albicans, but no sample could inhibit C. acnes. Furthermore, all samples demonstrated antioxidant activity. Interestingly, all Mucuna samples exhibited strong collagenase, elastase, and hyaluronidase inhibitory activities. We conclude that the ethanolic extracts of four Mucuna seeds are probably advantageous in the development of skincare cosmeceutical products.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85123735387&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/72563
ISSN: 20799284
Appears in Collections:CMUL: Journal Articles

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