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dc.contributor.authorRanchana Yeewaen_US
dc.contributor.authorPawita Chaiyaen_US
dc.contributor.authorSalinee Jantrapiromen_US
dc.contributor.authorVorasuk Shotelersuken_US
dc.contributor.authorLuca Lo Piccoloen_US
dc.date.accessioned2022-05-27T08:26:34Z-
dc.date.available2022-05-27T08:26:34Z-
dc.date.issued2022-03-01en_US
dc.identifier.issn14209071en_US
dc.identifier.issn1420682Xen_US
dc.identifier.other2-s2.0-85126420190en_US
dc.identifier.other10.1007/s00018-022-04218-0en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85126420190&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/72541-
dc.description.abstractThe so-called Yaf9, ENL, AF9, Taf14, and Sas5 (YEATS) domain-containing proteins, hereafter referred to as YD proteins, take control over the transcription by multiple steps of regulation either involving epigenetic remodelling of chromatin or guiding the processivity of RNA polymerase II to facilitate elongation-coupled mRNA 3′ processing. Interestingly, an increasing amount of evidence suggest a wider repertoire of YD protein’s functions spanning from non-coding RNA regulation, RNA-binding proteins networking, post-translational regulation of a few signalling transduction proteins and the spindle pole formation. However, such a large set of non-canonical roles is still poorly characterized. Notably, four paralogous of human YEATS domain family members, namely eleven-nineteen-leukaemia (ENL), ALL1-fused gene from chromosome 9 protein (AF9), YEATS2 and glioma amplified sequence 41 (GAS41), have a strong link to cancer yet new findings also highlight a potential novel role in neurological diseases. Here, in an attempt to more comprehensively understand the complexity of four YD proteins and to gain more insight into the novel functions they may accomplish in the neurons, we summarized the YD protein’s networks, systematically searched and reviewed the YD genetic variants associated with neurodevelopmental disorders and finally interrogated the model organism Drosophila melanogaster.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectNeuroscienceen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleMultifaceted roles of YEATS domain-containing proteins and novel links to neurological diseasesen_US
dc.typeJournalen_US
article.title.sourcetitleCellular and Molecular Life Sciencesen_US
article.volume79en_US
article.stream.affiliationsChulalongkorn Universityen_US
article.stream.affiliationsKing Chulalongkorn Memorial Hospitalen_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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