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dc.contributor.authorNapatsorn Imerben_US
dc.contributor.authorChanisa Thonusinen_US
dc.contributor.authorWasana Pratchayasakulen_US
dc.contributor.authorBusarin Arunsaken_US
dc.contributor.authorWichwara Nawaraen_US
dc.contributor.authorRatchaneevan Aeimlapaen_US
dc.contributor.authorNarattaphol Charoenphandhuen_US
dc.contributor.authorNipon Chattipakornen_US
dc.contributor.authorSiriporn C. Chattipakornen_US
dc.description.abstractAims: To investigate the effects of hyperbaric oxygen therapy (HBOT) on metabolic disturbance, aging and bone remodeling in D-galactose-induced aging rats with and without obesity by determining the metabolic parameters, aging and oxidative stress markers, bone turnover markers, bone microarchitecture, and bone biomechanical strength. Materials and methods: Male Wistar rats were fed either a normal diet (ND; n = 18) or a HFD (n = 12) for 22 weeks. At week 13, vehicle (0.9% NaCl) was injected into ND-fed rats (NDV; n = 6), while 150 mg/kg/day of D-galactose was injected into 12 ND-fed rats (NDD) and 12 HFD-fed rats (HFDD) for 10 weeks. At week 21, rats were treated with either sham (NDVS, NDDS, or HFDDS; n = 6/ group) or HBOT (NDDH, or HFDDH; n = 6/group) for 14 days. Rats were then euthanized. Blood samples, femora, and tibiae were collected. Key findings: Both NDD and HFDD groups developed aging as indicated by increased AGE level, increased inflammation and oxidative stress as shown by raised serum TNF-α and MDA levels, impaired bone remodeling as indicated by an increase in levels of CTX-1, TRACP-5b, and impaired bone structure/strength, when compared with those of the NDVS group. HFD aggravated these indicators of bone dyshomeostasis in D-galactose-treated rats. HBOT restored bone remodeling and bone structure/strength in the NDD group, however HBOT ameliorated bone dyshomeostasis in the HFDD group. Significance: HBOT is a potential intervention to decrease the risk of osteoporosis and bone fracture in aging with or without obesity.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleHyperbaric oxygen therapy improves age induced bone dyshomeostasis in non-obese and obese conditionsen_US
article.title.sourcetitleLife Sciencesen_US
article.volume295en_US Universityen_US of Molecular Biosciences, Mahidol Universityen_US Mai Universityen_US of Scienceen_US
Appears in Collections:CMUL: Journal Articles

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