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dc.contributor.authorChiranan Khanthamen_US
dc.contributor.authorPichchapa Linsaenkarten_US
dc.contributor.authorTanakarn Chaitepen_US
dc.contributor.authorPensak Jantrawuten_US
dc.contributor.authorChuda Chittasuphoen_US
dc.contributor.authorPornchai Rachtanapunen_US
dc.contributor.authorKittisak Jantanasakulwongen_US
dc.contributor.authorYuthana Phimolsiripolen_US
dc.contributor.authorSarana Rose Sommanoen_US
dc.contributor.authorChanakan Prom-U-thaien_US
dc.contributor.authorSansanee Jamjoden_US
dc.contributor.authorChaiwat Arjinen_US
dc.contributor.authorKorawan Sringarmen_US
dc.contributor.authorHouda Berradaen_US
dc.contributor.authorFrancisco J. Barbaen_US
dc.contributor.authorFrancisco David Carmonaen_US
dc.contributor.authorWutigri Nimlamoolen_US
dc.contributor.authorWarintorn Ruksiriwanichen_US
dc.description.abstractAndrogenetic alopecia (AGA), a hair loss disorder, is a genetic predisposition to sensitive androgens, inflammation, and oxidative stress. Unfortunately, current treatments with synthetic medicines contain a restricted mechanism along with side effects, whereas the bioactive constituents of plant extracts are multifunctional, with fewer side effects. The massive amounts of rice husk and bran are agricultural wastes that may cause pollution and environmental problems. Owing to these rationales, the local rice variety, Bue Bang 3 CMU (BB3CMU), which is grown in northern Thailand, was evaluated for the valuable utilization of rice by-products, husk (BB3CMU-H) and bran (BB3CMU-RB) extracts, for AGA treatment regarding antioxidant, anti-inflammatory, anti-andro-genic activities, and the characterization of bioactive compounds. Our study verified that BB3CMU-H had the highest level of polyphenols, contributing to its greater antioxidant activity. Conversely, BB3CMU-RB was the predominant source of tocopherols, resulting in better anti-androgenic activities regarding the downregulation of steroid 5α-reductase genes (SRD5A). Notably, anti-inflamma-tion via the attenuation of nitric oxide productions was observed in BB3CMU-H (0.06 ± 0.13 μM) and BB3CMU-RB (0.13 ± 0.01 μM), which were significantly comparable to diclofenac sodium salt (0.13 ± 0.19 μM). Therefore, the combination of BB3CMU-H and BB3CMU-RB could be utilized in cosmeceutical and pharmaceutical applications for AGA patients.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectEnvironmental Scienceen_US
dc.titleAntioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substancesen_US
article.volume11en_US de Granadaen_US de Valènciaen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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