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dc.contributor.authorHeba H. Mahbouben_US
dc.contributor.authorGhasem Rashidianen_US
dc.contributor.authorSeyed Hossein Hoseinifaren_US
dc.contributor.authorSamar Kamelen_US
dc.contributor.authorMahyar Zareen_US
dc.contributor.authorHamed Ghafarifarsanien_US
dc.contributor.authorSamah Attia Alghariben_US
dc.contributor.authorTossapol Moonmaneeen_US
dc.contributor.authorHien Van Doanen_US
dc.description.abstractThe use of nano-sized materials is increasingly growing, while consequent health and environmental risks are still disputed. On the other hand, plant extracts have been reported to improve fish general health status and enhance antioxidant capacity. Thus, the present study was aimed to assess potential effects of Allium hirtifolium extract (AHE) to fortify antioxidant responses of Common carp (Cyprinus carpio) exposed to foodborne Zinc oxide nanoparticles (ZnO-NPs). Five hundred and forty fish were randomly allocated into 18 tanks and received six diets including a basal diet (as control), basal diet incorporated with either 13 mg/kg (ZnO-25) or 26 mg/kg (ZnO-50) of ZnO-NPs, 1.5% AHE (AHE-1.5), and similar concentrations of ZnO-NPs plus AHE (ZnO-25-AHE) and (ZnO-50-AHE) for a period of 30 days. Results revealed that blood indices, stress biomarkers (glucose and cortisol), and antioxidant parameters and genes in AHE-1.5 group were significantly modulated and improved when compared to other groups (P < 0.05). In AHE-enriched groups, serum and liver tissue antioxidative parameters were enhanced as reflected in a noticeable decrease in malondialdehyde value and an increase in catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase. However, current results showed that diets incorporated with ZnO-NPs elevated the stress parameters besides a significant reduction for most measured biochemical parameters and AHE supplementation ameliorated these effects in terms of improving antioxidant parameters. In ZnO-25-AHE, and ZnO-50-AHE, the values for expression of GPx were found significantly (P < 0.05) different from that of ZnO-25 and ZnO-50. On the contrary, SOD showed a non-significant difference (P > 0.05) among control, ZnO-25, and ZnO-50-AHE, also in-between ZnO-25 and ZnO-25-AHE. The present results indicate that AHE supplementation could trigger antioxidant responses both at tissue and molecular levels suggesting its outstanding protective effects against foodborne toxicity of ZnO-NPs in Common carp.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectEnvironmental Scienceen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleProtective effects of Allium hirtifolium extract against foodborne toxicity of Zinc oxide nanoparticles in Common carp (Cyprinus carpio)en_US
article.title.sourcetitleComparative Biochemistry and Physiology Part - C: Toxicology and Pharmacologyen_US
article.volume257en_US Modares Universityen_US Universityen_US University of Agricultural Sciences and Natural Resourcesen_US Canal Universityen_USčeská Univerzita v Českých Budějovicíchen_US Universityen_US Mai Universityen_US Universityen_US Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residuesen_US
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