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dc.contributor.authorAnupong Joompangen_US
dc.contributor.authorWisarut Payoungkiattikunen_US
dc.contributor.authorJirayut Dansuken_US
dc.contributor.authorNapat Nuramrumen_US
dc.contributor.authorNisachon Jangprommaen_US
dc.contributor.authorSanti Phosrien_US
dc.contributor.authorBancha Mahongen_US
dc.contributor.authorSompong Klaynongsruangen_US
dc.date.accessioned2021-04-23T08:50:38Z-
dc.date.available2021-04-23T08:50:38Z-
dc.date.issued2021en_US
dc.identifier.citationChiang Mai Journal of Science 48, 1 (January 2021), 150-162en_US
dc.identifier.issn2465-3845en_US
dc.identifier.urihttps://epg.science.cmu.ac.th/ejournal/dl.php?journal_id=11447en_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/72047-
dc.descriptionThe Chiang Mai Journal of Science is an international English language peer-reviewed journal which is published in open access electronic format 6 times a year in January, March, May, July, September and November by the Faculty of Science, Chiang Mai University. Manuscripts in most areas of science are welcomed except in areas such as agriculture, engineering and medical science which are outside the scope of the Journal. Currently, we focus on manuscripts in biology, chemistry, physics, materials science and environmental science. Papers in mathematics statistics and computer science are also included but should be of an applied nature rather than purely theoretical. Manuscripts describing experiments on humans or animals are required to provide proof that all experiments have been carried out according to the ethical regulations of the respective institutional and/or governmental authorities and this should be clearly stated in the manuscript itself. The Editor reserves the right to reject manuscripts that fail to do so.en_US
dc.description.abstractThis research exhibited that soybean (var. CM. 60) seed protein (3.00 µg/µL protein) was able to inhibit mushroom tyrosinase toward both monophenolase (32.86%) and diphenolase (43.30%). ABTS radical was decreased by 9.30-90.12%, when using 0.016-0.50 µg/µL protein. NO in RAW 264.7 cells was reduced by 10.89-47.77%, when using 0.19-1.50 µg/µL protein. Additionally, a protection toward H2O2-induced HaCaT cell oxidation was also found. ABTSradical scavenging activity and the protection toward H2O2 were contributed by small proteins (<10 kDa) more than large proteins (>10 kDa). The potent protection of <10 kDa (1.50 µg/µg protein) against H2O2 induced HaCaT cell oxidation was observed by increasing the cell viability to be 46.67%, resulting from the decrease of ROS and cell apoptosis. Moreover, CM. 60 protein showed low cytotoxicity toward HaCaT cells and Vero cells. These results suggest that soybean protein could be developed as a safe and potent skin whitening agent. This research exhibited that soybean (var. CM. 60) seed protein (3.00 µg/µL protein) was able to inhibit mushroom tyrosinase toward both monophenolase (32.86%) and diphenolase (43.30%). ABTS radical was decreased by 9.30-90.12%, when using 0.016-0.50 µg/µL protein. NO in RAW 264.7 cells was reduced by 10.89-47.77%, when using 0.19-1.50 µg/µL protein. Additionally, a protection toward H2O2-induced HaCaT cell oxidation was also found. ABTSradical scavenging activity and the protection toward H2O2 were contributed by small proteins (<10 kDa) more than large proteins (>10 kDa). The potent protection of <10 kDa (1.50 µg/µg protein) against H2O2 induced HaCaT cell oxidation was observed by increasing the cell viability to be 46.67%, resulting from the decrease of ROS and cell apoptosis. Moreover, CM. 60 protein showed low cytotoxicity toward HaCaT cells and Vero cells. These results suggest that soybean protein could be developed as a safe and potent skin whitening agent.en_US
dc.language.isoEngen_US
dc.publisherFaculty of Science, Chiang Mai Universityen_US
dc.subjecttyrosinase inhibitionen_US
dc.subjectantioxidanen_US
dc.subjectsoybean proteinen_US
dc.subjectanti-inflammationen_US
dc.titleInvestigation of Skin Whitening Property of Soybean Seed Protein; Anti-tyrosinase, Anti-inflammation and Antioxidanten_US
Appears in Collections:CMUL: Journal Articles

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