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dc.contributor.authorAussara Panyaen_US
dc.contributor.authorNunghathai Sawasdeeen_US
dc.contributor.authorPucharee Songprakhonen_US
dc.contributor.authorYingmanee Tragoolpuaen_US
dc.contributor.authorSiriphorn Rotarayanonten_US
dc.contributor.authorKiattawee Choowongkomonen_US
dc.contributor.authorPa Thai Yenchitsomanusen_US
dc.description.abstractDengue virus (DENV) infection has become a critically important globally prevalent infectious disease, especially in tropical and subtropical countries. Since neither currently exists, there is an urgent need for an effective vaccine to prevent, and a specific drug to treat DENV infection. Therapeutic peptides represent an attractive alternative for development into anti-DENV drugs due to their safety and their diverse biological and chemical properties. We recently reported novel bioactive peptides extracted from the Asian medicinal plant Acacia catechu that efficiently inhibited all four DENV serotypes. In this study, we investigated the anti-DENV activity of a synthetic bioactive peptide derived from this plant. The most effective peptide (designated Pep-RTYM) inhibited DENV infection with a half-maximal inhibition concentration value of 7.9 μM. Time-of-addition study demonstrated that Pep-RTYM interacted with DENV particles and inhibited cellular entry. Pep-RTYM at 50 μM significantly reduced DENV production in Vero-kidney epithelial cells about 1000-fold, but it could decrease the virus production in Huh7 hepatocyte cells approximately 40-fold. Binding of Pep-RTYM to DENV particles may prevent virus interaction with cellular receptor and subsequent virus entry. This finding suggests a potential role of Pep-RTYM in the development of a novel anti-DENV drug.en_US
dc.subjectImmunology and Microbiologyen_US
dc.titleA Synthetic Bioactive Peptide Derived from the Asian Medicinal Plant Acacia catechu Binds to Dengue Virus and Inhibits Cell Entryen_US
article.volume12en_US Universityen_US of Medicine, Siriraj Hospital, Mahidol Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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