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dc.contributor.authorDaehun Kangen_US
dc.contributor.authorHang Joon Joen_US
dc.contributor.authorMyung Ho Inen_US
dc.contributor.authorUten Yarachen_US
dc.contributor.authorNolan K. Meyeren_US
dc.contributor.authorLydia J. Bardwell Speltzen_US
dc.contributor.authorErin M. Grayen_US
dc.contributor.authorJoshua D. Trzaskoen_US
dc.contributor.authorJohn Hustonen_US
dc.contributor.authorMatt A. Bernsteinen_US
dc.contributor.authorYunhong Shuen_US
dc.description.abstract© 2020 Institute of Physics and Engineering in Medicine. Improved gradient performance in an MRI system reduces distortion in echo planar imaging (EPI), which has been a key imaging method for functional studies. A lightweight, low-cryogen compact 3T MRI scanner (C3T) is capable of achieving 80 mT m-1 gradient amplitude with 700 T m-1 s-1 slew rate, in comparison with a conventional whole-body 3T MRI scanner (WB3T, 50 mT m-1 with 200 T m-1 s-1). We investigated benefits of the high-performance gradients in a high-spatial-resolution (1.5 mm isotropic) functional MRI study. Reduced echo spacing in the EPI pulse sequence inherently leads to less severe geometric distortion, which provided higher accuracy than with WB3T for registration between EPI and anatomical images. The cortical coverage of C3T datasets was improved by more accurate signal depiction (i.e. less dropout or pile-up). Resting-state functional analysis results showed that greater magnitude and extent in functional connectivity (FC) for the C3T than the WB3T when the selected seed region is susceptible to distortions, while the FC matrix for well-known brain networks showed little difference between the two scanners. This shows that the improved quality in EPI is particularly valuable for studying certain brain regions typically obscured by severe distortion.en_US
dc.subjectHealth Professionsen_US
dc.titleThe benefit of high-performance gradients on echo planar imaging for BOLD-based resting-state functional MRIen_US
article.title.sourcetitlePhysics in Medicine and Biologyen_US
article.volume65en_US Universityen_US Clinicen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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