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dc.contributor.authorNicha Komolmalaien_US
dc.contributor.authorSurawut Pongsiriweten_US
dc.contributor.authorNirush Lertprasertsukeen_US
dc.contributor.authorSuree Lekwanavijiten_US
dc.contributor.authorSompid Kintaraken_US
dc.contributor.authorEkarat Phattarataratipen_US
dc.contributor.authorAjiravudh Subarnbhesajen_US
dc.contributor.authorKittipong Dhanuthaien_US
dc.contributor.authorRisa Chaisuparaten_US
dc.contributor.authorAnak Iamaroonen_US
dc.description.abstract© 2020 Objectives: To identify the prevalence of high-risk human papillomavirus (HPV) genotypes 16 and 18 among patients with oral squamous cell carcinoma (OSCC) in Thailand and investigate the associations of p16 expression and HPV16/18 with the demographic, clinicopathologic, and risk parameters. Materials and Methods: A total of 403 formalin-fixed paraffin-embedded OSCC specimens from four centers in four regions were obtained. p16 expression was evaluated by immunohistochemistry. The detection of HPV16/18 DNA was performed by polymerase chain reaction. Results: Of all, 172 specimens (42.7%) were presented with amplifiable extracted DNA. Among these, 62.8% were positive for p16, 8.1% were positive for HPV16/18, and 5.8% were positive for both methods. Of all HPV-positive specimens, HPV18 was detected in 57.1%; HPV16 in 14.3%; and HPV16 and 18 (co-infection) in 28.6%. The prevalence of HPV16/18 varied between centers, with the highest rate in the northern center (20.0%). There was no significant correlation between p16 expression and HPV16/18. There were no significant associations of p16 expression and/or HPV16/18 with all variables. Conclusions: The prevalence of HPV16/18 infection in OSCC geographically varied in Thailand, with the highest rate in the northern region. Poor correlation between p16 and HPV16/18 suggests p16 not be used as a surrogate marker for HPV-positive OSCC.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleHuman Papillomavirus 16 and 18 Infection in Oral Cancer in Thailand: A Multicenter Studyen_US
article.title.sourcetitleAsian Pacific Journal of Cancer Preventionen_US
article.volume21en_US Universityen_US Kaen Universityen_US of Songkla Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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