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dc.contributor.authorRoghieh Safarien_US
dc.contributor.authorSeyed Hossein Hoseinifaren_US
dc.contributor.authorMaryam Dadaren_US
dc.contributor.authorHien Van Doanen_US
dc.description.abstract© 2020 Roghieh Safari et al., published by Sciendo 2020. The present study investigated possible effects of dietary malic acid on the expression of immunity, antioxidant and growth related genes expression as well as skin mucus immune parameters in common carp. Common carp (Cyprinus carpio) fingerlings were fed diets supplemented with different levels (0 [control], 0.5%, 1%, 2%) of malic acid (MA) for 60 days. The results revealed highest expression levels of immune-related genes (tnf-alpha, il1b, il8 and lyz) in skin of common carp fed 2% MA (P < 0.05). Regarding 1% MA treatment comparison with control group, significant difference was noticed just in case of lyz (P < 0.05). Evaluation of growth related genes expression revealed no significant difference between treatments (P > 0.05). The study of antioxidant related genes (gsta and gpx) in common carp skin fed with MA, showed significant difference between treated groups and control (P < 0.05). Carps fed with 2% MA had highest alkaline phosphatase activity in skin mucus compared other treated groups and control (P < 0.05). There were no significant difference between 0.5% and 1% and control (P > 0.05). The study of total protein and total immunoglobulin (Ig) in common carp skin musus revealed no alteration following MA treatment (P > 0.05). The present data demonstrated that feeding with MA altered immune and antioxidant genes expression in skin mucus of common carp.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.titleEnrichment of common carp (Cyprinus carpio) diet with Malic acid: Effects on skin mucosal immunity, antioxidant defecne and growth performanceen_US
article.title.sourcetitleAnnals of Animal Scienceen_US Vaccine &amp; Serum Research Institute, Iranen_US University of Agricultural Sciences and Natural Resourcesen_US Mai Universityen_US
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