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Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/70388
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dc.contributor.authorSirada Boonyaketgosonen_US
dc.contributor.authorYongle Duen_US
dc.contributor.authorAna L.Valenciano Murilloen_US
dc.contributor.authorMaria B. Casseraen_US
dc.contributor.authorDavid G.I. Kingstonen_US
dc.contributor.authorKongkiat Trisuwanen_US
dc.date.accessioned2020-10-14T08:28:53Z-
dc.date.available2020-10-14T08:28:53Z-
dc.date.issued2020-07-01en_US
dc.identifier.issn13475223en_US
dc.identifier.issn00092363en_US
dc.identifier.other2-s2.0-85087612768en_US
dc.identifier.other10.1248/cpb.c20-00080en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087612768&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/70388-
dc.description.abstract© 2020 The Pharmaceutical Society of Japan. Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 w ith IC50 values of 36.7 and 33.9 μM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 μM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 μM.en_US
dc.subjectChemistryen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleFlavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activitiesen_US
dc.typeJournalen_US
article.title.sourcetitleChemical and Pharmaceutical Bulletinen_US
article.volume68en_US
article.stream.affiliationsUniversity of Georgiaen_US
article.stream.affiliationsVirginia Polytechnic Institute and State Universityen_US
article.stream.affiliationsChiang Mai Universityen_US
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