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dc.contributor.authorLaongdao Thongnaken_US
dc.contributor.authorAnchalee Pongchaidechaen_US
dc.contributor.authorAnusorn Lungkaphinen_US
dc.description.abstract© 2019 Southern Society for Clinical Investigation The pathogenesis of diabetic kidney disease is a complex process caused by both glucotoxicity and lipotoxicity due to lipid accumulation. In cases of diabetic animals, lipid deposition is found in both tubular and glomerular portions of the kidneys, which are the major sites of diabetic nephropathy lesions. The aim of this review was to provide insights into the mechanisms that lead to the development of renal lipid accumulation and the effects of renal lipotoxicity in the diabetic condition. An increased number of lipogenic genes and a decreased number of lipid oxidation genes are also detected in diabetic kidneys, both of which lead to lipid accumulation. The induction of oxidative stress, inflammation, fibrosis and apoptosis caused by lipid accumulation and lipid metabolites is called lipotoxicity. Renal lipotoxicity due to derangement in lipid metabolism may be a pathogenic mechanism leading to diabetic nephropathy and renal dysfunction.en_US
dc.titleRenal Lipid Metabolism and Lipotoxicity in Diabetesen_US
article.title.sourcetitleAmerican Journal of the Medical Sciencesen_US
article.volume359en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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