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|Title:||Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol|
Muhammad Makshoof Atha
nucleophilic aromatic substitution
phase transfer catalyst
|Publisher:||Science Faculty of Chiang Mai University|
|Citation:||Chiang Mai Journal of Science 47, 1 (January 2020), 175-180|
|Abstract:||An efficient method for nucleophilic aromatic substitution of 2-chloroquinoline-3-carbaldehydes is described for the synthesis of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes. The protocol involves the effective use of phase transfer catalyst CTAB in combination with polyethyleneglycol-400 to obtain the desired products in less reaction time. The newly developed method is found superior to the previously reported methods due to easy work up and excellent yields.|
|Appears in Collections:||CMUL: Journal Articles|
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