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Title: Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol
Authors: Rubina Munir
Muhammad Makshoof Atha
Muhammad Zia-ur-Rehman
Noman Javid
Keywords: quinoline
nucleophilic aromatic substitution
phase transfer catalyst
Issue Date: 2020
Publisher: Science Faculty of Chiang Mai University
Citation: Chiang Mai Journal of Science 47, 1 (January 2020), 175-180
Abstract: An efficient method for nucleophilic aromatic substitution of 2-chloroquinoline-3-carbaldehydes is described for the synthesis of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes. The protocol involves the effective use of phase transfer catalyst CTAB in combination with polyethyleneglycol-400 to obtain the desired products in less reaction time. The newly developed method is found superior to the previously reported methods due to easy work up and excellent yields.
ISSN: 0125-2526
Appears in Collections:CMUL: Journal Articles

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