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Title: Formulation and Physicochemical Properties of Nanostructured Lipid Carriers from Beeswax and Rosemary oil as a Drug Carrier
Authors: Farhanim Mohd Latif
Yin Yin Teo
Misni Misran
Vicit Rizal Eh Suk
Kah Hin Low
Keywords: colloidal
rosemary oil
nanostructured lipid carriers
Issue Date: 2020
Publisher: Science Faculty of Chiang Mai University
Citation: Chiang Mai Journal of Science 47, 1 (January 2020), 114-126
Abstract: The toxicity and insolubility of drugs in water remain a significant problem and has led to the development of food-grade drug delivery systems such as nanostructured lipid carriers (NLCs). A stable colloidal suspension of NLCs was prepared from a natural source of lipids. NLCs composed of beeswax (BW), rosemary oil (RO), and poloxamer 188 (P188) were prepared using melt-emulsification combined with ultrasonication. The optimised formulation with the smallest particle size and highest magnitude of zeta potential was selected for loading with terbinafine hydrochloride (TBHCl). TBHCl is a synthetic allylamine drug that functions as an antifungal. The optimised formulation comprised 3.75 % BW, 1.25 % RO, 3 % P188, and 92 % deionised water (DW). The mean particle size and zeta potential of the optimised NLCs was 174 ± 2 nm and -36 ± 5 mV, respectively. The morphology of the NLCs was observed as spherical with a dense appearance in the TEM images. The encapsulation and loading efficiencies were found to be dependent on the amount of TBHCl. The release of TBHCl from the optimised formulation was 62.87 ± 0.04 % during the 48-hour analysis.
ISSN: 0125-2526
Appears in Collections:CMUL: Journal Articles

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