Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAranya Manosroien_US
dc.contributor.authorCharinya Chankhampanen_US
dc.contributor.authorBang On Kietthanakornen_US
dc.contributor.authorWarintorn Ruksiriwanichen_US
dc.contributor.authorPuxvadee Chaikulen_US
dc.contributor.authorKorawinwich Boonpisuttinanten_US
dc.contributor.authorMathukorn Sainakhamen_US
dc.contributor.authorWorapaka Manosroien_US
dc.contributor.authorTheeraphong Tangjaien_US
dc.contributor.authorJiradej Manosroien_US
dc.description.abstract© 2019, Chiang Mai University. All rights reserved. The fresh Hemp (Cannabis sativa L var. sativa) leaves and seeds were extracted by maceration in 95% ethanol and investigated for their biological activities. The percentage yields were 3.77±0.31 and 1.58±0.20%, respectively. For cosmeceutical activities, the leaf extract exhibited higher DPPH scavenging, metal chelating and tyrosinase inhibition activity than the seed extract. The leaf extract exhibited pro MMP-2 inhibition (56.27±5.98%) and active MMP-2 inhibition (100%) with the pro MMP-2 inhibition lower than ascorbic acid of 1.11 times. The melanin induction in B16F10 melanoma cells of the leaf extract was 1.06 and 2.22 times of the control and theophylline, respectively. Moreover, it showed 5a-reductase inhibition (13.57±3.21%), but lower than dutasteride of 3.78 times. For pharmaceutical activities, the leaf extract showed anti-bacterial activity on S. mutans which was lower than erythromycin of 17 times and anti-proliferation on HepG2 and KB cell lines (IC50 values=13.17±1.53 and 5.16±1.66 mg/ml), which were lower than doxorubicin of 2,800 and 3,000 time, respectively. The high apoptotic on HeLa cells of the leaf extract was observed at 13.26±7.40%. The seed extract showed lipid peroxidation inhibition and anti-bacterial activity on S. aureus higher than the leaf extract. This study has demonstrated the potential of the Hemp leaf extract which can be further developed for pharmaceutical and cosmeceutical application.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMaterials Scienceen_US
dc.subjectPhysics and Astronomyen_US
dc.titlePharmaceutical and cosmeceutical biological activities of hemp (cannabis sativa L var. sativa) leaf and seed extractsen_US
article.title.sourcetitleChiang Mai Journal of Scienceen_US
article.volume46en_US of Phayaoen_US University of Technology Thanyaburi (RMUTT)en_US Fah Luang Universityen_US Universityen_US Mai Universityen_US Mai Universityen_US Health and Beauty Research Centeren_US Flavours and Fragrances Industry Co.en_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.