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dc.contributor.authorSeyed Aliakbar Hedayatien_US
dc.contributor.authorHamed Ghafari Farsanien_US
dc.contributor.authorSaeid Shahbazi Naserabaden_US
dc.contributor.authorSeyed Hossein Hoseinifaren_US
dc.contributor.authorHien Van Doanen_US
dc.description.abstract© 2019 Elsevier Inc. The present study evaluated silver nanoparticle (AgNPs) toxicity using biomarkers of oxidative and metabolic stress, immunological impairment and cellular damage in zebrafish (Danio rerio), as well as the optimal dose of vitamin E neutralizing undesirable effects. Fish were fed for ten days and eight study groups were investigated: controls, AgNPs exposure alone (1.5 mg L−1) and combined with three different vitamin E doses (1.5 mg L−1 of AgNPs + vitamin E 100, 200 or 400 mg kg−1 of food), also one positive control group exposed to AgNO3 alone or combined with the same vitamin E doses. D. rerio exposed to AgNPs alone or combined with the lower vitamin E dose showed overall worse results in comparison with the control groups and the groups combining nanoparticles and 200 or 400 mg kg−1 of food of vitamin E-supplemented diet. AgNPs caused cell impairment by increasing LDH activity and cortisol levels, generated oxidative stress by inhibiting SOD and CAT activity and immunosuppression by inhibiting ACH50 and lysozyme activity. The groups exposed to Ag salt showed the same response-pattern found for the NPs groups, reinforcing that Ag toxicity of AgNPs is mediated by Ag+. In conclusion, although AgNPs are toxic to Danio rerio, vitamin E supplementation at 200 or 400 mg kg−1 can act protectively against its toxic effects.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectEnvironmental Scienceen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleProtective effect of dietary vitamin E on immunological and biochemical induction through silver nanoparticles (AgNPs) inclusion in diet and silver salt (AgNO<inf>3</inf>) exposure on Zebrafish (Danio rerio)en_US
article.title.sourcetitleComparative Biochemistry and Physiology Part - C: Toxicology and Pharmacologyen_US
article.volume222en_US Azad University, Yasuj Branchen_US Azad University, Shahrekord Branchen_US University of Agricultural Sciences and Natural Resourcesen_US Mai Universityen_US
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