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dc.contributor.authorMahmoud A.O. Dawooden_US
dc.contributor.authorShunsuke Koshioen_US
dc.contributor.authorAmr I. Zaineldinen_US
dc.contributor.authorHien Van Doanen_US
dc.contributor.authorEman Moustafa Moustafaen_US
dc.contributor.authorMohamed M. Abdel-Daimen_US
dc.contributor.authorM. Angeles Estebanen_US
dc.contributor.authorMohamed S. Hassaanen_US
dc.description.abstract© 2018, Springer Nature B.V. Dietary supplementation of selenium nanoparticles (Se-NPs) at different levels (0, 0.5, 1, and 2 mg kg−1diet) was evaluated to find out the effects on serum and skin immune responses as well as stress resistance in the red sea bream (Pagrus major). After 45 days of experimental trial, serum and mucosal immune responses were significantly high in fish fed 1 mg Se-NPs kg−1diet (P < 0.05). In this group, alternative complement pathway, total serum protein, antioxidant activity of catalase enzyme, serum bactericidal activity, serum lysozyme activity, and amounts of skin mucus secretions as well as stress resistance against low salinity stress increased significantly, when compared to fish fed Se-NP-free diet (P < 0.05). Furthermore, fish fed Se-NPs at 2 mg kg−1diet exhibited higher alternative complement pathway, total serum protein, mucus lysozyme activity, serum and mucus peroxidases, amount of mucus secreted, and tolerance against low salinity stress than the fish fed Se-NP-free diet (P < 0.05). Interestingly, the nitro blue tetrazolium activity in all groups fed with diets supplemented with Se-NPs are significantly higher than Se-NP-free diet (P < 0.05). The present results demonstrate that the dietary supplementation with Se-NPs (mainly from 1 to 2 mg kg−1level) could be useful for maintaining the overall health status of red sea bream.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleDietary supplementation of selenium nanoparticles modulated systemic and mucosal immune status and stress resistance of red sea bream (Pagrus major)en_US
article.title.sourcetitleFish Physiology and Biochemistryen_US Universityen_US Universityen_US Health Research Institute Egypten_US Mai Universityen_US Canal Universityen_US de Murciaen_US Institute of Oceanography and Fisheries (NIOF)en_US
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