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Title: Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death
Authors: Arintaya Phrommintikul
Nipon Chattipakorn
Keywords: Medicine
Issue Date: 20-Sep-2006
Abstract: Calcium (Ca2+) plays an important role as a messenger in the excitation-contraction coupling process of the myocardium. It is stored in the sarcoplasmic reticulum (SR) and released via a calcium release channel called the ryanodine receptor. Cardiac ryanodine receptor (RyR2) controls Ca2+release, which is essential for cardiac contractility. There are several molecules which bind and regulate the function of RyR2 including calstabin2, calmodulin, protein kinase A (PKA), phosphatase, sorcin and calsequestrin. Alteration of RyR2 and associated molecules can cause functional and/or structural changes of the heart, leading to heart failure and sudden cardiac death. In this review, the alteration of RyR2 and its regulatory proteins, and its roles in heart failure and sudden cardiac death, are discussed. Evidence of a possible novel therapy targeting RyR2 and its associated regulatory proteins, currently proposed by investigators, is also included in this article. © 2006 Elsevier Ireland Ltd. All rights reserved.
ISSN: 01675273
Appears in Collections:CMUL: Journal Articles

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