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dc.contributor.authorMasahiko Isakaen_US
dc.contributor.authorUrarat Srisanohen_US
dc.contributor.authorSukitaya Veeranondhaen_US
dc.contributor.authorWilunda Choowongen_US
dc.contributor.authorSaisamorn Lumyongen_US
dc.description.abstractBerkleasmins A-E, five new eremophilane sesquiterpenoids were isolated from the saprobic fungus Berkleasmium nigroapicale BCC 8220. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical means. Berkleasmins A and C exhibited cytotoxic activity against cancer cell-lines (NCI-H187, MCF-7, and KB) as well as nonmalignant Vero cells with IC50values of 1.1-7.5 μg/mL, and these compounds also showed antimalarial activity with respective IC50of 3.1 and 2.8 μg/mL. © 2009 Elsevier Ltd. All rights reserved.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleCytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220en_US
article.volume65en_US National Center for Genetic Engineering and Biotechnologyen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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