Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/57599
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFuanglada Tongpraserten_US
dc.contributor.authorKasemsri Srisupunditen_US
dc.contributor.authorSuchaya Luewanen_US
dc.contributor.authorKuntharee Traisrisilpen_US
dc.contributor.authorPhudit Jatavanen_US
dc.contributor.authorTheera Tongsongen_US
dc.date.accessioned2018-09-05T03:46:35Z-
dc.date.available2018-09-05T03:46:35Z-
dc.date.issued2017-10-01en_US
dc.identifier.issn10970223en_US
dc.identifier.issn01973851en_US
dc.identifier.other2-s2.0-85029106393en_US
dc.identifier.other10.1002/pd.5140en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029106393&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/57599-
dc.description.abstract© 2017 John Wiley & Sons, Ltd. Objective: To determine whether fetal isovolumetric time intervals can be an early sonographic marker of fetal anemia in fetuses with homozygous alpha thalassemia-1. Methods: Pregnancies at risk for fetal homozygous alpha thalassemia-1 disease at 18–22 weeks were recruited before cordocentesis for hemoglobin typing. Isovolumetric contraction time (ICT) and isovolumetric relaxation time (IRT) intervals were measured by placing pulsed wave Doppler sample volume within the left ventricle to obtain the mitral and aortic waveform. Time intervals were compared between the affected group of homozygous alpha thalassemia-1 fetuses and the unaffected group. Results: Among 70 fetuses at risk, 28 cases were diagnosed as affected by homozygous alpha thalassemia-1 disease. Mean ICT and ICT + IRT intervals in the affected group were significantly longer than in the unaffected group (47.9 ± 12.5 ms vs 35.0 ± 6.7 ms, p < 0.001; and 96.2 ± 13.6 ms vs 80.9 ± 10.6 ms, p < 0.001. ICT effectively predicted affected fetuses with 71.4% sensitivity and 78.6% specificity using a cutoff value ≥40 ms. Conclusions: Isovolumetric contraction time was significantly prolonged in fetal anemia from homozygous alpha thalassemia-1 during the early stage of hydropic changes. Because of its simple measurement and high efficacy, ICT can be a useful marker for prenatal screening of abnormal cardiac function in fetal anemia. © 2017 John Wiley & Sons, Ltd.en_US
dc.subjectMedicineen_US
dc.titleFetal isovolumetric time intervals as a marker of abnormal cardiac function in fetal anemia from homozygous alpha thalassemia-1 diseaseen_US
dc.typeJournalen_US
article.title.sourcetitlePrenatal Diagnosisen_US
article.volume37en_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.