Carboxymethyl cellulose-modified AgInS<inf>2</inf>nanoparticles: Synthesis, physicochemical properties, optical properties and their potential use as drug carriers

Abstract

Copyright © 2017 American Scientific Publishers All rights reserved. Carboxymethyl cellulose modified silver indium sulfide nanoparticles (CMC modified AgInS2NPs) were synthesized by a one-pot hydrothermal method. Phase purity, morphology and oxidation state were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). The presence of CMC on surface of nanoparticles was certified by Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). Photoluminescence (PL) and UV-visible spectroscopy were used to investigate optical properties and drug loading efficiency of the products. The CMC-AgInS2NPs provide good biocompatibility, low toxicity, water-dispersibility, fluorescence property and drug carrier capability. In this research, doxorubicin entrapping efficiency (DEE) and doxorubicin loading efficiency (DLE) were determined to be 50% and 14%, respectively. Investigation on cellular accumulation and cytotoxicity certified that the CMC-AgInS2NPs can be used as nanocarriers to deliver the therapeutic agent to the cancer cells and can play the role in the toxicity to the cancer cells.