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Title: Electrochemical Detection of Human Interleukin-15 using a Graphene Oxide-Modified Screen-Printed Carbon Electrode
Authors: Poachanee Norfun
Nuttee Suree
Nawee Kungwan
Winita Punyodom
Jaroon Jakmunee
Kontad Ounnunkad
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 3-May-2017
Abstract: © 2017 Taylor & Francis. Biofunctionalizing a simple and disposable graphene oxide-modified screen-printed carbon electrode with anti-interleukin-15 antibodies has been successfully demonstrated for the first time for the label-free electrochemical detection of interleukin-15, a biomarker of early HIV infection. To improve the electrochemical reactivity and introduce carboxylic groups on the surface of screen-printed carbon electrode, high-quality graphene oxide was used for the modification of screen-printed carbon electrode. With simple modification of the screen-printed carbon electrode, the device exhibited satisfactory sensitivity, selectivity, stability, reproducibility, and regenerability. The immunosensor provided a detection limit of 3.51 ng mL−1and a sensitivity of 0.5655 µA cm−2mL ng−1. The simply constructed immunosensor thus rendered promising device for immunoreactions on the surface of the electrode.
ISSN: 1532236X
Appears in Collections:CMUL: Journal Articles

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