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dc.contributor.authorSaowalak Krungchanuchaten_US
dc.contributor.authorTitipun Thongtemen_US
dc.contributor.authorSomchai Thongtemen_US
dc.contributor.authorChalermchai Pilapongen_US
dc.description.abstract© 2017 American Vacuum Society. Herein, a new magnetic resonance imaging (MRI) agent based on molecular nanoparticles of iron(III)-tannic complexes (Fe-TA NPs) is reported. The paramagnetic and molecularlike Fe-TA NPs were successfully synthesized at room temperature within a few minutes without the use of any toxic agents or expensive equipment. The coordination states of the Fe-TA NPs were pH-dependent. The r1 relaxivity values of the bis-dominated and tris-dominated structures of the Fe-TA NPs were determined to be 6.31 and 5.24mM-1s-1, respectively, by using a Philips Achieva 1.5T MRI scanner. The Fe-TA NPs were 177612nm in diameter (hydrodynamic size) with a zeta potential value of -28 ≈ 0.9mV, dispersing very well in aqueous solution and were highly stable in phosphate buffered saline buffer (pH 7.4) containing competitive ligands and metals. From in vitro studies, it was evident that the Fe-TA NPs exhibited good biocompatibility, with high cellular uptake in HepG2 cells. Clearly, the Fe-TA NPs were found to induce signal enhancement in the T1-weighted image of the HepG2 cells. As a result, it can be stated that the Fe-TA NPs may have the potential for being developed as low-cost and clinically translatable magnetic resonance imaging agents in the near future.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMaterials Scienceen_US
dc.subjectPhysics and Astronomyen_US
dc.titleCharacterization and cellular studies of molecular nanoparticle of iron (III)-tannic complexes; toward a low cost magnetic resonance imaging agenten_US
article.volume12en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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