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dc.contributor.authorJie Zhangen_US
dc.contributor.authorDan Miaoen_US
dc.contributor.authorWan Fang Zhuen_US
dc.contributor.authorJian Xuen_US
dc.contributor.authorWen Yuan Liuen_US
dc.contributor.authorWorapong Kitdamrongthamen_US
dc.contributor.authorJiradej Manosroien_US
dc.contributor.authorMasahiko Abeen_US
dc.contributor.authorToshihiro Akihisaen_US
dc.contributor.authorFeng Fengen_US
dc.date.accessioned2018-09-05T03:28:35Z-
dc.date.available2018-09-05T03:28:35Z-
dc.date.issued2017-12-01en_US
dc.identifier.issn16121880en_US
dc.identifier.issn16121872en_US
dc.identifier.other2-s2.0-85038555561en_US
dc.identifier.other10.1002/cbdv.201700404en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85038555561&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/56664-
dc.description.abstract© 2017 Wiley-VHCA AG, Zurich, Switzerland Seven phenolic compounds, 1 – 7, including a new organic acid gallate, mucic acid 1-ethyl 6-methyl ester 2-O-gallate (7), were isolated from the MeOH extract of the fruits of Phyllanthus emblica L. (Euphorbiaceae). The structures were elucidated on the basis of extensive spectroscopic analysis and comparison with literature data. Upon evaluated for their antioxidant abilities by 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assays. The inhibitory activities against melanogenesis in B16 melanoma cells induced by α-MSH, as well as cytotoxic activities against four human cancer cell lines were also evaluated. All phenolic compounds, 1 – 7, exhibited potent antioxidant abilities (DPPH: IC505.6 – 12.9 μm; ABTS: 0.87 – 8.43 μm Trolox/μm; FRAP: 1.01 – 5.79 μm Fe2+/μm, respectively). Besides, 5 – 7, also exhibited moderate inhibitory activities against melanogenesis (80.7 – 86.8% melanin content), even with no or low toxicity to the cells (93.5 – 101.6% cell viability) at a high concentration of 100 μm. Compounds 1 – 3 exhibited cytotoxic activity against one or more cell lines (IC5013.9 – 68.4%), and compound 1 with high tumor selectivity for A549 (SI 3.2).en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemical Engineeringen_US
dc.subjectChemistryen_US
dc.titleBiological Activities of Phenolics from the Fruits of Phyllanthus emblica L. (Euphorbiaceae)en_US
dc.typeJournalen_US
article.title.sourcetitleChemistry and Biodiversityen_US
article.volume14en_US
article.stream.affiliationsChina Pharmaceutical Universityen_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsTokyo University of Scienceen_US
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