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dc.contributor.authorSuporn Charumaneeen_US
dc.contributor.authorSiriporn Okonogien_US
dc.contributor.authorJakkapan Sirithunyalugen_US
dc.contributor.authorPeter Wolschannen_US
dc.contributor.authorHelmut Viernsteinen_US
dc.description.abstract© 2016 by the authors; licensee MDPI, Basel, Switzerland. The aim of the study was to investigate the solubility of piroxicam (Prx) depending on the inclusion complexation with various cyclodextrins (CDs) and on ethanol as a co-solvent. The phase-solubility method was applied to determine drug solubility in binary and ternary systems. The results showed that in systems consisting of the drug dissolved in ethanol–water mixtures, the drug solubility increased exponentially with a rising concentration of ethanol. The phase solubility measurements of the drug in aqueous solutions of CDs, β-CD and γ-CD exhibited diagrams of AL-type, whereas 2,6-dimethyl-β-CD revealed AP-type. The destabilizing effect of ethanol as a co-solvent was observed for all complexes regardless of the CD type, as a consequence of it the lowering of the complex formation constants. In systems with a higher concentration of ethanol, the drug solubility was increased in opposition to the decreasing complex formation constants. According to this study, the type of CDs played a more important role on the solubility of Prx, and the use of ethanol as a co-solvent exhibited no synergistic effect on the improvement of Prx solubility. The Prx solubility was increased again due to the better solubility in ethanol.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleEffect of cyclodextrin types and co-solvent on solubility of a poorly water soluble drugen_US
article.title.sourcetitleScientia Pharmaceuticaen_US
article.volume84en_US Mai Universityen_US Wienen_US
Appears in Collections:CMUL: Journal Articles

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