Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/56236
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dc.contributor.authorLinda Aurpibulen_US
dc.contributor.authorThanyawee Puthanakiten_US
dc.contributor.authorTavitiya Sudjaritruken_US
dc.contributor.authorPeninnah Oberdorferen_US
dc.contributor.authorTawalchaya Chotecharoentananen_US
dc.contributor.authorSineenart Taejaroenkulen_US
dc.contributor.authorNongyow Wongnumen_US
dc.contributor.authorVirat Sirisanthanaen_US
dc.date.accessioned2018-09-05T03:11:12Z-
dc.date.available2018-09-05T03:11:12Z-
dc.date.issued2016-01-01en_US
dc.identifier.issn20402058en_US
dc.identifier.issn13596535en_US
dc.identifier.other2-s2.0-84979902932en_US
dc.identifier.other10.3851/IMP2978en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84979902932&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/56236-
dc.description.abstract©2016 International Medical Press. Background: The National Access to Antiretroviral Program for People Living with HIV/AIDS was launched in Thailand in 2002. HIV-infected, antiretroviral-naive, severely immunosuppressed children were initiated on highly active combination antiretroviral treatment (cART). This study aimed to determine the long-term effectiveness of cART. Methods: Data were extracted from medical records. Primary end points were mortality rate, proportion of children who remained on first-line cART regimen and children with plasma HIV RNA level (pVL) <50 copies/ml at week 520. Results: From August 2002 to July 2003, 107 children were enrolled. The baseline median age was 7.6 years (IQR 5.7-10.0), the median CD4+T-cell count was 60 cells/mm3(IQR 21-272) and the median pVL was 5.37 log10copies/ml (IQR 5.01-5.76). The mortality rate during and after the first year was 3.7 and 0.006 deaths/100 person-years, respectively. At week 520, 90 (84%) continued to be actively followed. Their median age was 17.8 years (IQR 15.8-19.8). 73 (81% as-treated) remained on the first-line regimen, while 18 (20%) had switched to a second-line cART regimen, at the median time of 272 weeks (IQR 256-363) after the first-line cART initiation. 69 (77%) had pVL<50 copies/ml and the median CD4+T-cell count was 636 cells/mm3(IQR 466-804). 83 (92%) and 64 (71%) had CD4+T-cell counts ≥200 and >500 cells/mm3, respectively. Conclusions: Long-term virological control, favourable immunological outcomes and healthy survival was achieved in severely immunosuppressed, perinatally HIV-infected children who started first-line NNRTI-based cART. Continuing surveillance for long-term complications is warranted.en_US
dc.subjectMedicineen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleThe 10-year effectiveness of combination antiretroviral treatment in perinatally HIV-infected children participating in Thailand's National Access Programen_US
dc.typeJournalen_US
article.title.sourcetitleAntiviral Therapyen_US
article.volume21en_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsChulalongkorn Universityen_US
article.stream.affiliationsThe HIV Netherlands Australia Thailand Research Collaborationen_US
Appears in Collections:CMUL: Journal Articles

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