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dc.contributor.authorThaneeya Chankongen_US
dc.contributor.authorPareena Chotjumlongen_US
dc.contributor.authorThanapat Sastrarujien_US
dc.contributor.authorSurawut Pongsiriweten_US
dc.contributor.authorAnak Iamaroonen_US
dc.contributor.authorSuttichai Krisanaprakornkiten_US
dc.description.abstract© 2016 Background/purpose Although some studies have shown induction of cyclooxygenase 2 (COX-2) in oral lichen planus (OLP), an association between COX-2 upregulation and OLP clinical severity has not been investigated. Therefore, we aimed to compare COX-2 expression in OLP with that in normal oral tissues, and to determine correlations between COX-2 expression and both clinical criteria and visual analog scale (VAS) scores. Materials and methods COX-2 expression was studied in 25 OLP and 13 normal oral tissues by immunohistochemistry. Both clinical criteria and VAS scores were used to evaluate the clinical severity of OLP. The differences in COX-2 expression between OLP and normal tissues, and the correlations between COX-2 expression and clinical severity were determined by the nonparametric statistical tests. Results COX-2 expression was significantly increased in OLP epithelium when compared with normal epithelium (P < 0.001), and intense COX-2 staining in inflammatory infiltrates was observed in the OLP lamina propria. COX-2 expression in OLP epithelium and inflammatory infiltrates was significantly correlated with the clinical criteria score (r = 0.428, P = 0.007, and r = 0.681, P < 0.001, respectively), whereas a significant correlation with the VAS score was observed only in OLP inflammatory infiltrates (r = 0.605, P < 0.001). Conclusion Enhanced COX-2 expression in both OLP epithelium and inflammatory infiltrates correlates well with the clinical severity. An association between VAS score and COX-2 expression in OLP inflammatory infiltrates suggests an important role of additional COX-2 expression from inflammation in causing pain in OLP patients.en_US
dc.titleIncreased cyclooxygenase 2 expression in association with oral lichen planus severityen_US
article.title.sourcetitleJournal of Dental Sciencesen_US
article.volume11en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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