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Title: Anti-inflammatory effects of compounds from Polygonum odoratum
Authors: Siriporn Okonogi
Kantaporn Kheawfu
Wolfgang Holzer
Frank M. Unger
Helmut Viernstein
Monika Mueller
Keywords: Agricultural and Biological Sciences
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2016
Abstract: Polygonum odoratum is an edible plant traditionally used as an antidiabetic, antimicrobial, anti-inflammatory, and antitumor agent in Asia. The aim of the study was to evaluate the anti-inflammatory effect of P. Odoratum and the isolation and characterization of its main fractions. Extracts of the aerial parts were tested for anti-inflammatory activity as indicated by a change in the cytokine secretion in lipopolysaccharide-stimulated macrophages. After separation of the extract by reversed-phase high-performance liquid chromatography, the anti-inflammatory activity of the fractions was determined. Furthermore, the two main fractions were identified by nuclear magnetic resonance spectroscopy (1H- and13C-NMR). The ethanolic extract significantly reduced IL-6 secretion (IC5025 μg/mL). The two main fractions (5 and 7) significantly decreased IL-6 production with an IC50of 102 μM (5) and 77 μM (7), respectively, and were identified as scutellarein-7-glucoside (5) and quercitrin (7). Since inflammation plays a major role in various diseases with high prevalence globally, it may be of importance that P. Odoratum and its main constituents scutellarein-7-glucoside and quercitrin can be used as either an alternative or complementary treatment. Additionally, both are glycosides and their activity may be enhanced tremendously by deglycosylation by the gut microbiota.
ISSN: 15559475
Appears in Collections:CMUL: Journal Articles

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