Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/54842
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dc.contributor.authorVorawut Jearasakulpolen_US
dc.contributor.authorPramote Tipduangtaen_US
dc.contributor.authorSupanimit Teekachunhateanen_US
dc.contributor.authorNatthakarn Chiranthanuten_US
dc.contributor.authorSunee Chansakaowen_US
dc.date.accessioned2018-09-04T10:25:05Z-
dc.date.available2018-09-04T10:25:05Z-
dc.date.issued2015-01-01en_US
dc.identifier.issn09751491en_US
dc.identifier.other2-s2.0-84936886476en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84936886476&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/54842-
dc.description.abstract© 2015, International Journal of Pharmacy and Pharmaceutical Science. All right resurved. Objective: Develop an effective and stable tablet form of Liu Wei Di Huang (LWDH). Methods: LWDH extract was obtained by decoction (TC) and reflux with water (WR). Extracts were concentrated and analyzed by HPLC-PDA using loganin as the bioactive marker. Adsorbents, tablet strength and friability, and tablet quality and stability were evaluated. Results: Extraction of LWDH formula from raw materials using WR yielded higher concentrations of loganin than TC. The best formulation of LWDH tablets included Avicel®PH101, corn starch, purified talcum, magnesium stearate and Cab-osil® Conclusion: Extraction of LWDH formula using reflux with water produces higher yields than decoction. A suitable tablet formulation consists of dried water extract (38.83 %), corn starch (29.13 %), Avicel with about 97.40 % of the label amount of active marker. Excluding moisture from the product reduced marker degradation, suggesting a product shelf life 12+months. Finished tablets were uniform in weight, friability, disintegrated in<30 min, had good microbial and heavy metal contamination safety profiles and was stable. ®PH101 (29.13 %), purified talcum (0.97 %), magnesium stearate (0.97 %) and Cab-osil® (0.97 %) prepared by wet granulation. Excluding moisture from the product reduces product degradation, suggesting a shelf life of 12+months. LWDH tablets avoid traditional formulation problems (high dosages, unacceptable taste and odor, lack of product uniformity, contamination with microorganisms and heavy metals), and are a good alternative for patients and TCM practitioners.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleDevelopment of a tablet form of liu wei di huang extracten_US
dc.typeJournalen_US
article.title.sourcetitleInternational Journal of Pharmacy and Pharmaceutical Sciencesen_US
article.volume7en_US
article.stream.affiliationsChiang Mai Universityen_US
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