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dc.contributor.authorKunrada Inthawongen_US
dc.contributor.authorPimlak Charoenkwanen_US
dc.contributor.authorSuchaya Silvilairaten_US
dc.contributor.authorAdisak Tantiworawiten_US
dc.contributor.authorArintaya Phrommintikulen_US
dc.contributor.authorWorawut Choeypraserten_US
dc.contributor.authorRungrote Natesirinilkulen_US
dc.contributor.authorChate Siwasomboonen_US
dc.contributor.authorPannee Visrutaratnaen_US
dc.contributor.authorSomdet Srichairatanakoolen_US
dc.contributor.authorNipon Chattipakornen_US
dc.contributor.authorTorpong Sanguansermsrien_US
dc.description.abstract© W. S. Maney & Son Ltd 2015. Background: Pulmonary hypertension is a major cardiac complication in non-transfusion-dependent thalassemia (NTDT). Several clinical and laboratory parameters, including iron overload, have been shown to have a positive correlation with the incidence of pulmonary hypertension. Non-transferrin-bound iron (NTBI) is a form of free-plasma iron that is a good indicator of iron overload. Objectives: The aim of this study was to determine the prevalence of pulmonary hypertension in patients with NTDT and to investigate its correlation with the clinical parameters, liver iron concentration (LIC) and NTBI. Methods: Patients with NTDT were evaluated using echocardiography, and magnetic resonance imaging for cardiac T2* and LIC. Pulmonary hypertension was defined as peak tricuspid regurgitation velocity ≥2.9 m/s measured using trans-thoracic echocardiography. Clinical parameters and the status of iron overload as determined by LIC, serum ferritin, and NTBI level were evaluated for their association with pulmonary hypertension. Results: Of 76 NTDT patients, mean age 23.7 ± 8.5 years, seven patients (9.2%) had pulmonary hypertension. Previous splenectomy (71.4 vs. 24.6%, P-value 0.019), higher cumulative red blood cell (RBC) transfusions (received ≥10 RBC transfusions 85.7 vs. 33.3%, P-value 0.011), higher nucleated RBCs (353 ± 287 vs. 63 ± 160/100 white blood cells, P-value <0.001), and a high NTBI level (5.7 ± 3.0 vs. 3.3 ± 2.8 μmol/l, P-value 0.034) were associated with pulmonary hypertension. There was no significant correlation between LIC or serum ferritin and pulmonary hypertension. Conclusion: Pulmonary hypertension in NTDT is common, and is associated with splenectomy and its related factors. NTBI level shows a significant correlation with pulmonary hypertension.en_US
dc.titlePulmonary hypertension in non-transfusion-dependent thalassemia: Correlation with clinical parameters, liver iron concentration, and non-transferrin-bound ironen_US
article.volume20en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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