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dc.contributor.authorSukanya Keawsa-Arden_US
dc.contributor.authorBoonsom Liawruangrathen_US
dc.contributor.authorSamart Kongtaweelerten_US
dc.description.abstract© 2015 Chiang Mai University. All rights reserved. The chemical constituents and biological activities of Mesua ferrea Linn. were studied. The stems of M. ferrea were extracted with hexane, dichloromethane and methanol, respectively. The methanol extract exhibited the highest antibacterial activity against Escherichia coli with the MIC value of 31.25 μg/mL. The methanol extract and the dichloromethane extract exhibited the highest activity against Staphylococcus aureus with the MIC values of 31.25 μg/mL. The dichloromethane extract exhibited anticancer activities against KB-oral, MCF-7 and NCI-H187 cell lines with the IC50values of 18.01, 28.83 and 18.42 μg/mL, respectively. Friedelin, the mixture of α-amyrin and β-amyrin, lupeol and β-sitosterol were isolated from the active dichloromethane extract of the stems. Friedelin, the mixture of α-amyrin and β-amyrin, lupeol and β-sitosterol showed the antibacterial activity against E. coli with the MIC values of 250, 250, 250 and 1000 μg/mL, respectively. They also showed antibacterial activity against S. aureus with the MIC values of 250, 250, 500 and 1000 μg/mL, respectively. The mixture of α-amyrin and β-amyrin exhibited anticancer activity against MCF-7 cell line with the IC50value 28.45 μg/mL and lupeol exhibited anticancer activities against KB, MCF-7 and NCI-H187 cell lines with the IC50values of 30.12, 34.25 and 21.56 μg/mL, respectively. All the extracts and the isolated compounds were non-cytotoxic to Vero cells.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMaterials Scienceen_US
dc.subjectPhysics and Astronomyen_US
dc.titleBioactive compounds from Mesua ferrea stemsen_US
article.title.sourcetitleChiang Mai Journal of Scienceen_US
article.volume42en_US Universityen_US Mai Universityen_US Mongkut's Institute of Technology Ladkrabangen_US
Appears in Collections:CMUL: Journal Articles

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